Mitochondrial genetic variants identified to be associated with posttraumatic stress disorder.

Translational Psychiatry
Antònia FlaquerKonstantin Strauch

Abstract

Despite the fact that mitochondrial dysfunctions are increasingly recognized as key components in stress-related mental disorders, very little is known about the association between posttraumatic stress disorder (PTSD) and mitochondrial variants. To identify susceptibility mitochondrial genes for PTSD, we analyzed a total number of 978 mitochondrial single-nucleotide polymorphisms (mtSNPs) in a sample of 1238 individuals participating in the KORA (Cooperative Health Research in the Region of Augsburg) study. Participants were classified with 'no PTSD', 'partial PTSD' or 'full PTSD' by applying the Posttraumatic Diagnostic Scale and the Impact of Event Scale. To assess PTSD-mtSNP association while taking heteroplasmy into account, we used the raw signal intensity values measured on the microarray and applied linear regression. Significant associations were obtained between full versus no PTSD and two mtSNPs; mt8414C->T (β=-0.954±0.06, Padjusted=0.037) located in adenosine triphosphate (ATP) synthase subunit 8 (MT-ATP8) and mt12501G->A (β=-1.782±0.40, Padjusted=0.015) located in the NADH dehydrogenase subunits 5 (MT-ND5). Heteroplasmy for the two variants towards a larger number of the respective minor alleles increases the risk ...Continue Reading

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Citations

Feb 24, 2016·Drug Development Research·Walter H MoosKosta Steliou
Nov 26, 2015·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Janitza L Montalvo-OrtizJoan Kaufman
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Jun 14, 2021·Journal of Equine Veterinary Science·Xi YuShipeng Lv
Nov 16, 2021·Frontiers in Cellular Neuroscience·Adonis SferaZisis Kozlakidis

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Methods Mentioned

BETA
blood draw
chip
chips
genotyping

Software Mentioned

R

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