PMID: 8441651Feb 11, 1993Paper

Mitochondrial genome expression in a mutant strain of D. subobscura, an animal model for large scale mtDNA deletion

Nucleic Acids Research
F BéziatS Alziari

Abstract

A mitochondrial mutant strain of D. subobscura has two mitochondrial genome populations (heteroplasmy): the first (20-30% of the population, 15.9 kb) is the same as could be found in the wild type; the second (70-80% of the population, 11 kb) has lost by deletion several genes coding for complex I and III subunits, and four tRNAs. In human pathology, this kind of mutation has been correlated with severe diseases such as the Kearns-Sayre syndrome, but the mutant strain, does not seem to be affected by the mutation (1). Studies reported here show that: a) Transcripts from genes not concerned by the mutation are present at the same level in both strains. b) In contrast, transcript concentrations from genes involved in the deletion are significantly decreased (30-50%) in the mutant. c) Deleted DNA was expressed as shown by the detection of the fusion transcript. d) The mtDNA/nuc.DNA ratio is 1.5 times higher in the mutant strain than in the wild type. The mutation leads to change in the transcript level equilibrium. The apparent innocuousness of the mutation may suggest some post-transcriptional compensation mechanisms. This drosophila strain is an interesting model to study the consequence of this type of mitochondrial genome dele...Continue Reading

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Citations

Oct 8, 1999·Insect Biochemistry and Molecular Biology·F MorelS Alziari
Feb 16, 2002·European Journal of Biochemistry·Géraldine FargeSerge Alziari
Sep 5, 2006·In Vitro Cellular & Developmental Biology. Animal·F MorelS Alziari
Jul 11, 2003·Biochimica Et Biophysica Acta·William Y Tsang, Bernard D Lemire
Dec 4, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Joseph James DubieUlfar Bergthorsson
Nov 24, 1999·The Journal of Biological Chemistry·R RossignolT Letellier
Sep 30, 2020·Nature Reviews. Genetics·James B Stewart, Patrick F Chinnery

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