Mitochondrial genome mutations in hypertensive individuals

American Journal of Hypertension
Faina SchwartzHaralambos Gavras

Abstract

Human essential hypertension (HTN), a polygenic, multifactorial, and highly heterogeneous disorder of unknown etiology, has been shown to have excess maternal transmission in several studies, suggesting a possible mitochondrial involvement. In an effort to assess the contribution of the mitochondrial genome to HTN we initiated a systematic, extended screening of hypertensive individuals to identify potentially pathogenic mtDNA mutations. We applied our newly developed novel class of tests for the detection of mitochondrial mutation involvement in complex diseases to the hypertension data set from 350 pedigrees of white ethnicity and 98 of African American ethnicity ascertained at HTN clinics associated with Boston Medical Center, and we identified families with a likely mitochondrial involvement. We analyzed the sequence of the entire mitochondrial genome in probands from 20 such pedigrees, consisting of 10 African American and 10 white families. Comparison with the reference "Cambridge" sequence revealed a total of 297 base changes, including 24 in the ribosomal RNA (rRNA) genes, 15 in the transfer RNA (tRNA) genes, and 46 amino acid substitutions, with the remainder involving the noncoding regions or synonymous changes. Among...Continue Reading

Citations

Dec 16, 2010·Molecular & Cellular Proteomics : MCP·Gaetano VattemiGiuliano Tomelleri
Mar 14, 2007·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Louise PiloteVicky Tagalakis
Jun 21, 2011·Yi chuan = Hereditas·Zong-Bin LiShi-Wen Wang
Sep 29, 2011·Yi chuan = Hereditas·Ling XueMin-Xin Guan
Mar 1, 2006·Expert Opinion on Investigational Drugs·Jerry R Colca, Rolf F Kletzien
Oct 6, 2011·Clinical Science·Pietro MinuzGiuliano Tomelleri
Jun 16, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Jie WangXun Fan
Jun 8, 2007·Biology of Reproduction·B M ActonR F Casper
Nov 3, 2009·The Journal of Pathology·Amy J McKnightAlexander P Maxwell
Mar 4, 2014·Journal of the American Heart Association·Gabriele Giacomo SchiattarellaGiovanni Esposito
Dec 28, 2006·Hypertension·Alan B Weder
Feb 17, 2006·Current Opinion in Nephrology and Hypertension·Martin W McBrideAnna F Dominiczak
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Dov HershkovitzBarry M Brenner
Jun 24, 2008·Blood Pressure·Paolo PudduAntonio Muscari
Nov 26, 2019·Journal of Inherited Metabolic Disease·Caroline Chong-NguyenKarim Wahbi
Feb 3, 2005·Current Opinion in Nephrology and Hypertension·Yoram Yagil, Chana Yagil
Feb 9, 2006·Clinical Science·Maolian Gong, Norbert Hubner
Feb 25, 2021·The Journal of Gene Medicine·Yu DingJinyu Huang
Sep 26, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hai-Yan ZhuMin-Lu Zhang
Jan 8, 2008·Biochemical and Biophysical Research Communications·Zongbin LiMin-Xin Guan
Jan 16, 2008·Biochemical and Biophysical Research Communications·Yuqi LiuMin-Xin Guan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.