Mitochondrial Haplogroup T Is Associated with Obesity in Austrian Juveniles and Adults

PloS One
Sabine EbnerDaniel Weghuber

Abstract

Recent publications have reported contradictory data regarding mitochondrial DNA (mtDNA) variation and its association with body mass index. The aim of the present study was to compare the frequencies of mtDNA haplogroups as well as control region (CR) polymorphisms of obese juveniles (n = 248) and obese adults (n = 1003) versus normal weight controls (njuvenile = 266, nadults = 595) in a well-defined, ethnically homogenous, age-matched comparative cohort of Austrian Caucasians. Using SNP analysis and DNA sequencing, we identified the nine major European mitochondrial haplogroups and CR polymorphisms. Of these, only the T haplogroup frequency was increased in the juvenile obese cohort versus the control subjects [11.7% in obese vs. 6.4% in controls], although statistical significance was lost after adjustment for sex and age. Similar data were observed in a local adult cohort, in which haplogroup T was found at a significantly higher frequency in the overweight and obese subjects than in the normal weight group [9.7% vs. 6.2%, p = 0.012, adjusted for sex and age]. When all obese subjects were considered together, the difference in the frequency of haplogroup T was even more clearly seen [10.1% vs. 6.3%, p = 0.002, OR (95% CI) 1...Continue Reading

Associated Clinical Trials

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Citations

Feb 2, 2018·European Journal of Clinical Nutrition·Nicola VeroneseStefania Maggi
Jun 4, 2019·International Journal of Legal Medicine·Laura KytövuoriMika H Martikainen
Mar 3, 2020·Journal of Inherited Metabolic Disease·Sofiya GanchevaRegina Ensenauer
Apr 20, 2018·Nature Reviews. Rheumatology·Francisco J BlancoIgnacio Rego-Pérez
Sep 27, 2020·Clinical Rheumatology·Francisco J Blanco, Ignacio Rego-Pérez
Jan 15, 2021·Scientific Reports·Mohammed DashtiThangavel Alphonse Thanaraj
Mar 7, 2021·Mitochondrion·María Del Mar GonzálezMaria Pilar Aluja
Apr 4, 2021·Animals : an Open Access Journal From MDPI·Clara Heumann-KieslerMartin Hasselmann
Jun 20, 2021·American Journal of Human Biology : the Official Journal of the Human Biology Council·Volney K FriedrichTheodore G Schurr

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Datasets Mentioned

BETA
J01415

Methods Mentioned

BETA
PCR

Clinical Trials Mentioned

NCT00482924

Software Mentioned

Blast
Phylotree
Chromas
GeneBank
PASW
MITOMAP
SPSS

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