Mitochondrial impairment in the developing brain after hypoxia-ischemia

Journal of Bioenergetics and Biomembranes
Henrik Hagberg

Abstract

The pattern of cell death in the immature brain differs from that seen in the adult CNS. During normal development, more than half of the neurons are removed through apoptosis, and mediators like caspase-3 are highly upregulated. The contribution of apoptotic mechanisms in cell death appears also to be substantial in the developing brain, with a marked activation of downstream caspases and signs of DNA fragmentation. Mitochondria are important regulators of cell death through their role in energy metabolism and calcium homeostasis, and their ability to release apoptogenic proteins and to produce reactive oxygen species. We find that secondary brain injury is preceded by impairment of mitochondrial respiration, signs of membrane permeability transition, intramitochondrial accumulation of calcium, changes in the Bcl-2 family proteins, release of proapoptotic proteins (cytochrome C, apoptosis inducing factor) and downstream activation of caspase-9 and caspase-3 after hypoxia-ischemia. These data support the involvement of mitochondria-related mechanisms in perinatal brain injury.

Citations

Sep 29, 2006·Anesthesiology·Stanley Muravchick, Richard J Levy
Aug 30, 2008·Stroke; a Journal of Cerebral Circulation·Wei YinJun Chen
May 24, 2008·Anesthesia and Analgesia·Vincent DegosPierre Gressens
Feb 22, 2011·Pharmacogenomics·Fayçal MouaffakMarie Odile Krebs
Nov 18, 2008·Annales Françaises D'anesthèsie Et De Rèanimation·V DegosJ Mantz
Mar 1, 2012·Neurology Research International·Claire ThorntonHenrik Hagberg
Mar 26, 2011·Lancet Neurology·Michael V JohnstonFrances Northington
Nov 10, 2009·Trends in Molecular Medicine·M O KrebsHelge Frieling
Apr 6, 2016·Neural Plasticity·Eridan Rocha-Ferreira, Mariya Hristova
Nov 17, 2007·Progress in Neurobiology·Rabih S TalhoukMarwan E El-Sabban
Mar 21, 2007·Seminars in Fetal & Neonatal Medicine·Elie SalibaPierre Gressens
Dec 7, 2006·Clinics in Perinatology·Saraid S BilliardsHannah C Kinney
Apr 4, 2007·Journal of Neurochemistry·Courtney L RobertsonGary Fiskum
Apr 12, 2006·Journal of Neurochemistry·Santina A ZanelliNina J Solenski
Sep 18, 2007·Journal of Neurochemistry·Michelle BurgosFernando A González
Nov 8, 2011·Mitochondrion·Simone N WeisCarlos Alexandre Netto
Sep 30, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Kenneth M TichauerKeith S Lawrence
Jun 6, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Katarina JärlestedtMarcela Pekna
Jun 10, 2017·Oncotarget·Qingyi Ma, Lubo Zhang
May 11, 2019·International Journal of Molecular Sciences·Maryam ArdalanCarina Mallard
Sep 3, 2010·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Serafina PerroneGiuseppe Buonocore
Nov 24, 2011·Journal of Bioenergetics and Biomembranes·Natalia PavónEdmundo Chávez
Sep 8, 2017·Frontiers in Cellular Neuroscience·Claire ThorntonHenrik Hagberg
Oct 12, 2017·Frontiers in Cellular Neuroscience·Yonggang LuanYubin Dong
Jun 3, 2021·International Journal of Molecular Sciences·Raymand PangNicola J Robertson

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