PMID: 9529388May 16, 1998Paper

Mitochondrial inheritance is delayed in Saccharomyces cerevisiae cells lacking the serine/threonine phosphatase PTC1

Molecular Biology of the Cell
A D RoederJ M Shaw

Abstract

In wild-type yeast mitochondrial inheritance occurs early in the cell cycle concomitant with bud emergence. Cells lacking the PTC1 gene initially produce buds without a mitochondrial compartment; however, these buds later receive part of the mitochondrial network from the mother cell. Thus, the loss of PTC1 causes a delay, but not a complete block, in mitochondrial transport. PTC1 encodes a serine/threonine phosphatase in the high-osmolarity glycerol response (HOG) pathway. The mitochondrial inheritance delay in the ptc1 mutant is not attributable to changes in intracellular glycerol concentrations or defects in the organization of the actin cytoskeleton. Moreover, epistasis experiments with ptc1delta and mutations in HOG pathway kinases reveal that PTC1 is not acting through the HOG pathway to control the timing of mitochondrial inheritance. Instead, PTC1 may be acting either directly or through a different signaling pathway to affect the mitochondrial transport machinery in the cell. These studies indicate that the timing of mitochondrial transport in wild-type cells is genetically controlled and provide new evidence that mitochondrial inheritance does not depend on a physical link between the mitochondrial network and the in...Continue Reading

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Citations

Mar 22, 2002·Molecular Biology of the Cell·Kai Stefan DimmerBenedikt Westermann
Nov 16, 2010·Eukaryotic Cell·Joaquín AriñoAsier González
Mar 11, 2009·Molecular and Cellular Biology·Asier GonzálezJoaquín Ariño
Jun 6, 2000·Microbiology and Molecular Biology Reviews : MMBR·V Contamine, M Picard
Feb 5, 2008·Genetics·Rebecca L FrederickJanet M Shaw
Oct 24, 1998·The Journal of Cell Biology·D OtsugaJ M Shaw
Oct 24, 1998·The Journal of Cell Biology·G J HermannJ M Shaw
Jan 8, 2008·Current Opinion in Microbiology·Andrei Fagarasanu, Richard A Rachubinski
Oct 5, 2010·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Leonardo Peraza-ReyesLiza A Pon
Dec 14, 2011·Current Biology : CB·Heidi M McBride
Aug 13, 2008·Biochimica Et Biophysica Acta·Vincent Soubannier, Heidi M McBride
Feb 20, 2014·Biochemical and Biophysical Research Communications·Nils Johnsson
Jan 19, 1999·Annual Review of Cell and Developmental Biology·G J Hermann, J M Shaw
Sep 16, 2006·The EMBO Journal·Yunrui DuSusan Ferro-Novick
Jun 16, 2017·The Journal of Cell Biology·Stefan BöcklerBenedikt Westermann
Jan 23, 2020·Biological Chemistry·Till Klecker, Benedikt Westermann
Jun 8, 2001·Traffic·I R BoldoghL A Pon
Feb 6, 2021·Advances in Biological Regulation·Sara Wong, Lois S Weisman
May 6, 2004·Journal of Cell Science·Paul D GavinRodney J Devenish

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