Mitochondrial injury and cognitive function in HIV infection and methamphetamine use

AIDS
Susanna R VarJosué Pérez-Santiago

Abstract

In this work, we evaluated the association of human immunodeficiency virus (HIV) infection and methamphetamine (METH) use with mitochondrial injury in the brain and its implication on neurocognitive impairment. Mitochondria carry their genome (mtDNA) and play a critical role in cellular processes in the central nervous system. METH is commonly used in HIV-infected populations. HIV infection and METH use can cause damage to mtDNA and lead to neurocognitive morbidity. We evaluated HIV infection and METH use with mitochondrial injury in the brain. We obtained white and gray matter from Brodmann areas 7, 8, 9, 46 of the following: HIV-infected individuals with history of past METH use (HIV+METH+, n = 16), HIV-infected individuals with no history of past METH use (HIV+METH-, n = 11), and HIV-negative controls (HIV-METH-, n = 30). We used the 'common deletion', a 4977 bp mutation, as a measurement of mitochondrial injury, and quantified levels of mtDNA and 'common deletion' by droplet digital PCR, and evaluated in relation to neurocognitive functioning [Global Deficit Score (GDS)]. Levels of mtDNA and mitochondrial injury were highest in white matter of Brodmann area 46. A higher relative proportion of mtDNA carrying the 'common dele...Continue Reading

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Citations

Aug 4, 2016·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Virawudh SoontornniyomkijUNKNOWN Translational Methamphetamine AIDS Research Center (TMARC) Group
Oct 13, 2018·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Marta MassanellaSanjay R Mehta
Aug 15, 2017·The Journal of the Association of Nurses in AIDS Care : JANAC·David E VancePariya L Fazeli
Nov 5, 2017·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Jun PaneeLinda Chang
Nov 18, 2018·International Journal of Molecular Sciences·Ian Simon OlivierVinogran Naidoo
Sep 16, 2020·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Rowan SalonerUNKNOWN Translational Methamphetamine AIDS Research Center (TMARC) Group
Jul 30, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Todd Hulgan, David C Samuels
Jul 30, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Carla Roca-BayerriBrendan A I Payne
Mar 31, 2021·Sleep·Michael J LeoneM Brandon Westover

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Methods Mentioned

BETA
PCR
ELISA

Software Mentioned

QuantaSoft
R

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