Nov 27, 2019

Mitochondrial MiRNA in Cardiovascular Function and Disease

Rui SongLubo Zhang


MicroRNAs (miRNAs) are small noncoding RNAs functioning as crucial post-transcriptional regulators of gene expression involved in cardiovascular development and health. Recently, mitochondrial miRNAs (mitomiRs) have been shown to modulate the translational activity of the mitochondrial genome and regulating mitochondrial protein expression and function. Although mitochondria have been verified to be essential for the development and as a therapeutic target for cardiovascular diseases, we are just beginning to understand the roles of mitomiRs in the regulation of crucial biological processes, including energy metabolism, oxidative stress, inflammation, and apoptosis. In this review, we summarize recent findings regarding how mitomiRs impact on mitochondrial gene expression and mitochondrial function, which may help us better understand the contribution of mitomiRs to both the regulation of cardiovascular function under physiological conditions and the pathogenesis of cardiovascular diseases.

  • References105
  • Citations1


  • References105
  • Citations1


Mentioned in this Paper

Post-Transcriptional Regulation
RNA, Untranslated
Mitochondrial Inheritance
Regulation of Biological Process
Energy Metabolism
Cardiovascular System Function
Oxidative Stress
Protein Biosynthesis
Gene Expression

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.


Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Related Papers

Canadian Journal of Physiology and Pharmacology
Rohini BaradanSamarjit Das
Advances in Experimental Medicine and Biology
Filipe V DuarteAnabela P Rolo
Advances in Experimental Medicine and Biology
Samarjit DasRamesh Parjapath
Frontiers in Physiology
Carolina Jaquenod De GiustiSamarjit Das
© 2020 Meta ULC. All rights reserved