Mitochondrial preprotein translocase

Annual Review of Cell and Developmental Biology
N PfannerA Hönlinger

Abstract

Mitochondria import most of their proteins from the cytosol. Dynamic protein complexes in the mitochondrial outer and inner membranes are responsible for the specific recognition and membrane translocation of preproteins. The preprotein translocase of the outer mitochondrial membrane contains several import receptors and a general import pore. The preprotein translocase of the inner membrane consists of a channel interacting with preproteins in transit and an import motor that includes the matrix heat shock protein Hsp70. Acidic patches of import components are thought to guide the import of positively charged signal sequences (acid chain hypothesis). Energy input is derived from the inner membrane potential and ATP. Proteins in the mitochondrial matrix are required for proteolytic processing and folding of imported proteins. The dynamic nature of the membrane translocase permits sorting of preproteins at distinct stages of the import pathway.

References

Jan 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·D Roise
Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·P E SchererM Horst
Dec 13, 1991·Science·H SchneiderN Pfanner
Dec 1, 1991·The Journal of Cell Biology·U WienhuesW Neupert
Aug 1, 1990·Current Opinion in Cell Biology·A Horwich
Jul 13, 1990·Cell·T SöllnerW Neupert
Dec 1, 1990·The Journal of Cell Biology·H F StegerN Pfanner
Nov 2, 1990·Cell·W NeupertN Pfanner
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·E A CraigJ Kosic-Smithers
Jul 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·A MatouschekG Schatz
Jul 1, 1995·Trends in Biochemical Sciences·J R LambP Hieter
Jan 1, 1993·Annual Review of Biophysics and Biomolecular Structure·F X Schmid
Apr 1, 1995·The Journal of Cell Biology·S GratzerM Horst
Feb 1, 1995·Current Biology : CB·N Pfanner, M Meijer
Dec 20, 1994·Proceedings of the National Academy of Sciences of the United States of America·N G KronidouM Horst
Jul 1, 1994·The Journal of Cell Biology·J Höhfeld, F U Hartl
Oct 27, 1994·Nature·H C SchneiderW Neupert

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Citations

Mar 21, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·K Mihara
Jan 28, 2004·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Aurora O'Brate, Paraskevi Giannakakou
May 6, 2003·Archives of Biochemistry and Biophysics·Aida UribeFederico Martínez
May 30, 2001·Advanced Drug Delivery Reviews·A MuratovskaM P Murphy
Mar 4, 2000·Advanced Drug Delivery Reviews·M P Murphy, R A Smith
Feb 13, 2001·Trends in Biochemical Sciences·K GabrielT Lithgow
Feb 8, 2000·The International Journal of Biochemistry & Cell Biology·M T RyanN Pfanner
Apr 4, 2000·Current Opinion in Microbiology·J M Herrmann, W Neupert
Sep 6, 2000·Current Opinion in Microbiology·S D Dyall, P J Johnson
Dec 29, 2012·The Journal of Biological Chemistry·Prasad TammineniNaresh Babu Venkata Sepuri
Oct 8, 1999·Molecular Biology of the Cell·U Fünfschilling, S Rospert
Aug 6, 1999·Molecular Biology of the Cell·C E NabholzA Schneider
May 22, 2001·Molecular Biology of the Cell·D RapaportF E Nargang
Mar 22, 2001·EMBO Reports·A MatouschekW Voos
May 24, 2005·Plant Physiology·Amy BaldwinPaul Jarvis
Apr 24, 1999·The Plant Cell·K Keegstra, K Cline
Apr 25, 2000·Molecular and Cellular Biology·C VoisineE A Craig
Dec 28, 1999·Annual Review of Cell and Developmental Biology·A E Johnson, M A van Waes
Oct 14, 2000·Annual Review of Cell and Developmental Biology·R E Dalbey, A Kuhn
Oct 12, 2004·Annual Review of Cell and Developmental Biology·Carla M Koehler
Nov 15, 2000·Biological Chemistry·U C Vothknecht, J Soll
Nov 13, 2002·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·P KopecekE Weigl
Oct 16, 1999·Proceedings of the National Academy of Sciences of the United States of America·M EsakiT Endo
Oct 16, 1999·Proceedings of the National Academy of Sciences of the United States of America·K DiekertR Lill
Jul 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Wing-Hang TongTracey A Rouault

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Methods Mentioned

BETA
nucleotide exchange

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