PMID: 12787657Jun 6, 2003Paper

Mitochondrial profiling of dog hairs

Forensic Science International : Synergy
Jon H WettonAiden P Foster

Abstract

In order to make greater use of dog hairs as forensic evidence, we have developed a robust method for duplex amplification of adjacent 306 and 332bp amplicons within the 5' hypervariable region (5' HVR) of the canine mitochondrial control region. In support of this, a 595bp region covering 35 polymorphic sites has been sequenced from the blood of 105 UK dogs. In total, 30 different haplotypes were observed, 13 only once whilst the commonest was seen 14 times; the overall exclusion capacity is 0.929. One animal was heteroplasmic in blood for a single base deletion and showed phenotypes ranging from near complete deletion to a predominance of the base among a sample of 12 hairs. In contrast, no evidence of heteroplasmy was seen in single hairs from 20 dogs which were not visibly heteroplasmic in blood. Phylogenetic analysis and comparisons with other published databases highlighted instances of possible recurrent mutation which may be relevant when interpreting single base differences between samples.

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Citations

Jan 16, 2007·International Journal of Legal Medicine·Cordula Eichmann, Walther Parson
Nov 5, 2010·International Journal of Legal Medicine·Cornelya F C KlütschPeter Savolainen
Jun 1, 2007·Forensic Science, Medicine, and Pathology·E A M Graham
Dec 1, 2009·Forensic Science, Medicine, and Pathology·Yasser Said El-SayedSalah M Abd El-Rahman
Apr 6, 2004·Forensic Science International : Synergy·Luísa PereiraAntónio Amorim
Apr 6, 2004·Forensic Science International : Synergy·I PfeifferB Brenig
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Apr 15, 2011·Forensic Science International. Genetics·Stijn Desmyter, Leonie Gijsbers
Apr 10, 2009·Genesis : the Journal of Genetics and Development·So Gun HongByeong Chun Lee
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