Mitochondrial Proteins Containing Coiled-Coil-Helix-Coiled-Coil-Helix (CHCH) Domains in Health and Disease

Trends in Biochemical Sciences
Nazanine ModjtahediGuido Kroemer

Abstract

Members of the coiled-coil-helix-coiled-coil-helix (CHCH) domain-containing protein family that carry (CX9C) type motifs are imported into the mitochondrion with the help of the disulfide relay-dependent MIA import pathway. These evolutionarily conserved proteins are emerging as new cellular factors that control mitochondrial respiration, redox regulation, lipid homeostasis, and membrane ultrastructure and dynamics. We discuss recent insights on the activity of known (CX9C) motif-carrying proteins in mammals and review current data implicating the Mia40/CHCHD4 import machinery in the regulation of their mitochondrial import. Recent findings and the identification of disease-associated mutations in specific (CX9C) motif-carrying proteins have highlighted members of this family of proteins as potential therapeutic targets in a variety of human disorders.

References

Nov 1, 1996·European Journal of Biochemistry·M G Claros, P Vincens
Dec 5, 1998·American Journal of Human Genetics·J LoeffenL van den Heuvel
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·C M KoehlerG Schatz
Jan 20, 2004·Trends in Biochemical Sciences·Carla M Koehler
Jan 22, 2004·Nature Reviews. Genetics·Jeremy N TimmisWilliam Martin
Feb 20, 2004·The Journal of Biological Chemistry·Hui LuKostas Tokatlidis
May 26, 2004·Neurology·Vincent Procaccio, Douglas C Wallace
Aug 3, 2004·Science·Douglas R Green, Guido Kroemer
Sep 11, 2004·The EMBO Journal·Agnieszka ChacinskaNikolaus Pfanner
Sep 15, 2004·The Journal of Biological Chemistry·Mari NaoéToshiya Endo
Nov 5, 2004·The EMBO Journal·Nicola VahsenGuido Kroemer
Mar 1, 2005·Cancer Research·Woong-Ryeon Park, Yusuke Nakamura
Sep 27, 2005·Journal of Molecular Biology·Michael RisslerAgnieszka Chacinska
May 9, 2006·Biochimica Et Biophysica Acta·Vladimir GogvadzeBoris Zhivotovsky
Jul 22, 2006·Science·Pavel DolezalTrevor Lithgow
Nov 11, 2006·Journal of Molecular Biology·Kipros GabrielChris Meisinger
Jan 24, 2007·Physiological Reviews·Guido KroemerCatherine Brenner
Feb 16, 2007·Biochimica Et Biophysica Acta·James A MacKenzie, R Mark Payne
Nov 2, 2007·The EMBO Journal·Deepa V DabirCarla M Koehler
May 24, 2008·American Journal of Human Genetics·Valeria MassaMassimo Zeviani
May 27, 2008·Eukaryotic Cell·Oleh KhalimonchukDennis R Winge
Jul 11, 2008·Cell·David J PagliariniVamsi K Mootha
Sep 10, 2008·The Journal of Biological Chemistry·Agnieszka ChacinskaNikolaus Pfanner
Feb 3, 2009·Nature Structural & Molecular Biology·Lucia BanciKostas Tokatlidis
May 19, 2009·Journal of Molecular Biology·Irina F Sevrioukova
Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Shin KawanoToshiya Endo
Aug 26, 2009·Cell·Agnieszka ChacinskaNikolaus Pfanner
Aug 26, 2009·Journal of Molecular Biology·Sebastian LongenJan Riemer

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Citations

Apr 12, 2016·Current Opinion in Cell Biology·Martin van der LaanNikolaus Pfanner
Aug 9, 2016·Molecular Cell·Brendan J FloydDavid J Pagliarini
Aug 21, 2016·Cell and Tissue Research·Alican J Erdogan, Jan Riemer
Sep 11, 2016·Biochimica Et Biophysica Acta. Molecular Cell Research·Heike RampeltNikolaus Pfanner
May 21, 2017·Biochimica Et Biophysica Acta. Molecular Cell Research·Florian WollweberMartin van der Laan
Mar 21, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yinfang WangPeng Zhang
Aug 8, 2018·Human Molecular Genetics·Xiaoping HuangDerek P Narendra
Aug 22, 2018·British Journal of Pharmacology·Markus HabichJan Riemer
Nov 21, 2018·PLoS Genetics·Anna M SokolAgnieszka Chacinska
Sep 19, 2019·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Wei ZhouEng-King Tan
Jul 8, 2017·Oxidative Medicine and Cellular Longevity·Lawrence I GrossmanSiddhesh Aras
May 13, 2017·Frontiers in Oncology·Luke W ThomasMargaret Ashcroft
Sep 12, 2018·ELife·Diego HuetSebastian Lourido
Mar 16, 2018·The Journal of Biological Chemistry·Neeraja PurandareSiddhesh Aras
Jan 8, 2020·Cell Death and Differentiation·Wei LiuChao Tong
Nov 4, 2017·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Mika SaitoToshiki Nakamura
Aug 28, 2020·The Biochemical Journal·Karthik MohanrajAgnieszka Chacinska
Feb 28, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Camille ReinhardtNazanine Modjtahedi
May 11, 2021·Frontiers in Aging Neuroscience·Teresa R KeeJung-A A Woo

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