Mitochondrial proteomics investigation of frontal cortex in an animal model of depression: Focus on chronic antidepressant drugs treatment

Pharmacological Reports : PR
Katarzyna GłombikA Basta-Kaim

Abstract

Alteration in the brain mitochondrial functions have been suggested to participate, as a relevant factor, in the development of mental disorders. Therefore, the brain mitochondria may be a crucial therapeutic target in the course of depression. Our goal was to find out the impact of two antidepressant drugs with various mechanisms of action - imipramine and fluoxetine, on the frontal cortex mitochondria-enriched fraction in an animal model of depression based on the prenatal stress procedure. Our results confirmed that the prenatal stress caused depressive-like disturbances in the adult offspring rats, which were normalized by the chronic imipramine and fluoxetine administration. For the first time, using 2D-LC-MS/MS, we demonstrated nine differentially expressed proteins after the imipramine administration. Of these proteins, the up-regulation of the 2',3'-cyclic-nucleotide 3'-phosphodiesterase enzyme and down-regulation of the Hypoxanthine-guanine phosphoribosyltransferase (HPRT), Ras-related proteins (Rap-1A and Rap-1B) and Transgelin-3 (NP25) were the most striking. In contrast, after the chronic fluoxetine treatment, we observed differential expression in five proteins, including the enhanced expression of component of pyr...Continue Reading

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Citations

Feb 6, 2020·Mass Spectrometry Reviews·Na Li, Xianquan Zhan
Nov 16, 2019·Current Neuropharmacology·Katarzyna ChameraAgnieszka Basta-Kaim
Aug 9, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·David A Lovejoy, David W Hogg
Sep 27, 2020·Molecular and Cellular Neurosciences·Virginie RappeneauChadi Touma
Dec 22, 2020·Frontiers in Neuroscience·Katarzyna GłombikBogusława Budziszewska
May 18, 2021·Neuroscience and Biobehavioral Reviews·Tim L EmmerzaalTamas Kozicz

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