Mitochondrial Q cycle-derived superoxide and chemiosmotic bioenergetics

Annals of the New York Academy of Sciences
Shu-Sen Liu

Abstract

We examined the intrinsic relation between two interdependent and interacted processes, namely, chemiosmotic energy coupling partition and redox signaling involved in mitochondrial respiration. The following aspects of research were conducted and discussed: generation sites and release sidedness of superoxide from the Q cycle of complex III of the mitochondrial respiratory chain; the different physiological roles of PMF components, DeltaPsi and DeltapH (DeltapH(S)), of the Q cycle in mitochondrial superoxide generating and partitioning; and direct feedback effects of Q cycle-derived O(2)(*-) on PMF energy partition through its interaction with protons in DeltapH(S) to form HO(2)(*), leading to decreasing DeltapH(S) and ATP synthesis due to its increasing effects of basic proton leak of mitochondria. The present experimental data give new evidence for our hypothesis of reactive oxygen species cycle cooperation with Q cycle and H(+) cycle in respiratory chain in keeping PMF energy partition and its equilibrium with redox signaling regulation of mitochondrial respiration.

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Citations

Jun 6, 2012·PloS One·Wenbin MaHector Martinez-Valdez
May 9, 2014·PloS One·Adrian Reyes-PrietoOscar Juárez
Feb 26, 2016·Biophysical Journal·Jason N BazilKalyan C Vinnakota
Jul 19, 2011·Free Radical Biology & Medicine·Ryan J Mailloux, Mary-Ellen Harper
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Dec 15, 2016·Frontiers in Pharmacology·Elizabeth J PereiraKevin A Janes
Jul 20, 2021·Frontiers in Cell and Developmental Biology·Jannatul AklimaYoshihiro Ohta

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