Mitochondrial quality control in AMD: does mitophagy play a pivotal role?

Cellular and Molecular Life Sciences : CMLS
Juha M T HyttinenJanusz Błasiak

Abstract

Age-related macular degeneration (AMD) is the predominant cause of visual loss in old people in the developed world, whose incidence is increasing. This disease is caused by the decrease in macular function, due to the degeneration of retinal pigment epithelium (RPE) cells. The aged retina is characterised by increased levels of reactive oxygen species (ROS), impaired autophagy, and DNA damage that are linked to AMD pathogenesis. Mitophagy, a mitochondria-specific type of autophagy, is an essential part of mitochondrial quality control, the collective mechanism responsible for this organelle's homeostasis. The abundance of ROS, DNA damage, and the excessive energy consumption in the ageing retina all contribute to the degeneration of RPE cells and their mitochondria. We discuss the role of mitophagy in the cell and argue that its impairment may play a role in AMD pathogenesis. Thus, mitophagy as a potential therapeutic target in AMD and other degenerative diseases is as well explored.

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Citations

Nov 23, 2019·International Journal of Molecular Sciences·Juha M T HyttinenKai Kaarniranta
Jan 4, 2020·Cellular and Molecular Life Sciences : CMLS·Janusz Blasiak
Apr 17, 2020·Fundamental & Clinical Pharmacology·Jinjin JiangJing Chen
Apr 11, 2020·Oxidative Medicine and Cellular Longevity·Ming-Xuan WangYa-Juan Zheng
Aug 25, 2020·Oxidative Medicine and Cellular Longevity·Zi-Yuan ZhangGuang-Yu Li
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Dec 4, 2020·International Journal of Molecular Sciences·Janusz BlasiakKai Kaarniranta
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Apr 17, 2020·Progress in Retinal and Eye Research·Kai KaarnirantaDeborah Ferrington
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Mar 23, 2021·Cellular and Molecular Life Sciences : CMLS·Angela ArmentoSimon J Clark
Apr 28, 2020·Ecotoxicology and Environmental Safety·Na ChenXianjin Xiao

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Methods Mentioned

BETA
GTPase
transmission electron microscopy
lipidation
ubiquitination
gene knock-out

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