Mitochondrial quality control mechanisms as potential therapeutic targets in sepsis-induced multiple organ failure

Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte
You WuZhong-Qiu Lu

Abstract

Sepsis is a dysregulated response to severe infection characterized by life-threatening organ failure and is the leading cause of mortality worldwide. Multiple organ failure is the central characteristic of sepsis and is associated with poor outcome of septic patients. Ultrastructural damage to the mitochondria and mitochondrial dysfunction are reported in sepsis. Mitochondrial dysfunction with subsequent ATP deficiency, excessive reactive oxygen species (ROS) release, and cytochrome c release are all considered to contribute to organ failure. Consistent mitochondrial dysfunction leads to reduced mitochondrial quality control capacity, which eliminates dysfunctional and superfluous mitochondria to maintain mitochondrial homeostasis. Mitochondrial quality is controlled through a series of processes including mitochondrial biogenesis, mitochondrial dynamics, mitophagy, and transport processes. Several studies have indicated that multiple organ failure is ameliorated by restoring mitochondrial quality control mechanisms and is further amplified by defective quality control mechanisms. This review will focus on advances concerning potential mechanisms in regulating mitochondrial quality control and impacts of mitochondrial quality ...Continue Reading

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Citations

Jun 9, 2020·Acute and Critical Care·Reverien HabimanaInseok Jeong
Nov 2, 2019·International Journal of Molecular Sciences·Min HuangJingqian Su
Oct 20, 2020·Frontiers in Cellular and Infection Microbiology·Qun LinZiyong Sun
Jan 27, 2021·Critical Care : the Official Journal of the Critical Care Forum·Elisabeth C van der SlikkeHjalmar R Bouma
Jan 29, 2021·Pediatric Research·Junsung ParkWon Kyoung Jhang
May 28, 2021·Acta Pharmacologica Sinica·Chao DengYang Yang

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