Jun 10, 2018

Mitochondrial regulation in skeletal muscle: A role for non-coding RNAs?

Experimental Physiology
Jessica SilverSéverine Lamon

Abstract

What is the topic of this review? This article draws evidence from the current literature to support the hypothesis that non-coding RNA-mediated gene regulation takes place in the mitochondria. An emphasis is put on skeletal muscle. What advances does it highlight? This review highlights the potential role of microRNAs and long non-coding RNAs in mitochondrial gene regulation. The discovery of a new level of skeletal muscle mitochondria-controlled gene regulation presents exciting perspectives for our understanding of skeletal muscle physiology in health and disease. Skeletal muscle is a highly metabolic tissue characterized by high mitochondrial abundance. As such, skeletal muscle homeostasis relies on the tight control of mitochondrial gene expression to ensure efficient mitochondrial function. Mitochondria retain a conserved genome from prokaryotic ancestors, and mitochondrial gene regulation relies on communication between mitochondrial- and nuclear-encoded transcripts. Small and long non-coding RNAs (ncRNAs) have regulatory roles in the modulation of gene expression. Emerging evidence demonstrates that regulatory ncRNAs, particularly microRNAs (miRNAs) and long ncRNAs (lncRNAs), localize within the mitochondria in diverse ...Continue Reading

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Mentioned in this Paper

Metabolic Process, Cellular
Research
Muscle Physiology
Genome
RNA, Untranslated
Mitochondrial Inheritance
Regulation of Biological Process
Soleus Muscle Structure
Gene Expression
MIRN-181c microRNA, human

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