Mitochondrial regulation of cytosolic Ca²⁺ signals in smooth muscle.

Pflügers Archiv : European journal of physiology
John G McCarronSusan Chalmers

Abstract

The cytosolic Ca²⁺ concentration ([Ca²⁺]c) controls virtually every activity of smooth muscle, including contraction, migration, transcription, division and apoptosis. These processes may be activated by large (>10 μM) amplitude [Ca²⁺]c increases, which occur in small restricted regions of the cell or by smaller (<1 μM) amplitude changes throughout the bulk cytoplasm. Mitochondria contribute to the regulation of these signals by taking up Ca²⁺. However, mitochondria's reported low affinity for Ca²⁺ is thought to require the organelle to be positioned close to ion channels and within a microdomain of high [Ca²⁺]. In cultured smooth muscle, mitochondria are highly dynamic structures but in native smooth muscle mitochondria are immobile, apparently strategically positioned organelles that regulate the upstroke and amplitude of IP₃-evoked Ca²⁺ signals and IP₃ receptor (IP₃R) cluster activity. These observations suggest mitochondria are positioned within the high [Ca²⁺] microdomain arising from an IP₃R cluster to exert significant local control of channel activity. On the other hand, neither the upstroke nor amplitude of voltage-dependent Ca²⁺ entry is modulated by mitochondria; rather, it is the declining phase of the transient tha...Continue Reading

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Citations

Jun 13, 2012·Pflügers Archiv : European journal of physiology·Andras Spät, Ole H Petersen
Feb 7, 2013·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Gregory C Amberg, Manuel F Navedo
Jan 12, 2013·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·John G McCarronSusan Chalmers
Mar 29, 2014·Pharmacological Reviews·Marie BillaudBrant E Isakson
Aug 17, 2016·Oncotarget·Sona HudecovaOlga Krizanova
Sep 30, 2014·Journal of Cardiovascular Pharmacology·Amy C KellerJane E B Reusch
Apr 16, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Matthew W MillerJane E B Reusch
Nov 21, 2019·Scientific Reports·Arash MoshkforoushB Rita Alevriadou
May 4, 2021·Molecular Nutrition & Food Research·Xueqin FengDongmei Man

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