Mitochondrial remodeling in cancer metabolism and survival: potential for new therapies

Biochimica Et Biophysica Acta
Inês A BarbosaPaulo J Oliveira

Abstract

Mitochondria are semi-autonomous organelles that play essential roles in cellular metabolism and programmed cell death pathways. Genomic, functional and structural mitochondrial alterations have been associated with cancer. Some of those alterations may provide a selective advantage to cells, allowing them to survive and grow under stresses created by oncogenesis. Due to the specific alterations that occur in cancer cell mitochondria, these organelles may provide promising targets for cancer therapy. The development of drugs that specifically target metabolic and mitochondrial alterations in tumor cells has become a matter of interest in recent years, with several molecules undergoing clinical trials. This review focuses on the most relevant mitochondrial alterations found in tumor cells, their contribution to cancer progression and survival, and potential usefulness for stratification and therapy.

References

Jun 1, 1992·Human Molecular Genetics·I Savre-TrainJ W Shay
Sep 1, 1989·Genes, Chromosomes & Cancer·C WelterN Blin
Dec 1, 1988·Molecular and Cellular Biochemistry·L W Oberley, T D Oberley
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M J WeissL B Chen
Sep 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·I C SummerhayesL B Chen
Apr 9, 1981·Nature·S AndersonI G Young
Jan 1, 1995·Journal of Cancer Research and Clinical Oncology·M TetefS Shibata
Jan 1, 1994·Cancer Chemotherapy and Pharmacology·C H HolschneiderF J Montz
Feb 14, 1994·FEBS Letters·E J WolvetangA W Linnane
Jan 1, 1996·Cancer Chemotherapy and Pharmacology·G S PriceD E Thrall
Aug 2, 1996·Cancer Letters·B C Liang, L Hays
Jan 23, 1999·Current Opinion in Oncology·J C Reed
Mar 11, 1999·Cancer Chemotherapy and Pharmacology·N TatsutaL B Chen
Jun 3, 2000·Annual Review of Pharmacology and Toxicology·K B Wallace, A A Starkov
Jun 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·J L WangZ Huang
May 30, 2001·Advanced Drug Delivery Reviews·J S Modica-Napolitano, J R Aprille
Feb 19, 2002·Neurochemistry International·Pierre CasellasAnthony S Basile
Apr 30, 2002·Experimental Cell Research·Robert SternBent Formby
May 11, 2002·Nature Reviews. Cancer·Frederik H Igney, Peter H Krammer
Feb 4, 2003·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Azucena González-ColomaDiego Cortes
May 6, 2003·Drugs of Today·Serena Di CosimoFrancesco Cognetti
Feb 24, 1956·Science·O WARBURG
Sep 23, 2003·Diabetes & Metabolism·X M LeverveN F Wiernsperger
Nov 15, 2003·Toxicology Letters·M Carmo BarretoM Leonor Pavão
Dec 4, 2003·Biochemical Society Transactions·L BehrendR M Zwacka
Feb 12, 2004·Cancer Research·Rodrigue RossignolRoderick A Capaldi
Apr 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Wen-Chien ChouChi V Dang
May 26, 2004·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Helene PelicanoPeng Huang

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Citations

Dec 5, 2012·ISRN Oncology·Josep J Centelles
Aug 20, 2014·BioMed Research International·Mojtaba TalariJalal Pourahmad
Apr 16, 2014·Trends in Cell Biology·Andrea RasolaDidier Picard
Jun 5, 2016·Biochemistry. Biokhimii︠a︡·P V MaximchikV G Gogvadze
Mar 25, 2014·Expert Opinion on Investigational Drugs·Frances E Lennon, Ravi Salgia
Jul 5, 2013·Kidney International·Oscar C Y YangPatrick J Pollard
Sep 5, 2015·Redox Biology·Agnes GörlachThomas Kietzmann
Dec 21, 2012·Chemical Biology & Drug Design·Sergio GiannattasioLoredana Moro
Feb 27, 2013·IUBMB Life·Anna Olszewska, Adam Szewczyk
Dec 20, 2014·European Journal of Clinical Investigation·André FerreiraTeresa Cunha-Oliveira
Apr 29, 2015·Journal of Cellular Physiology·Mirabelle S H HoDuncan J Stewart
Jun 25, 2015·Frontiers in Oncology·Valeria Poli, Annalisa Camporeale
Oct 22, 2013·Biochimica Et Biophysica Acta·An S TanMichael V Berridge
Aug 21, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Aphrodite T ChoumessiVéronique B Penlap
Nov 26, 2015·BioMed Research International·Massimiliano Cazzaniga, Bernardo Bonanni
Feb 28, 2018·Immunology·Sultan DamgaciRobert J Gillies
Jul 12, 2014·Human Reproduction Update·Sandro L PereiraJoão Ramalho-Santos
Apr 14, 2019·Bioscience Reports·Cheng LiJianxiang Qiu
May 31, 2017·Current Medicinal Chemistry·José TeixeiraPaulo J Oliveira
Apr 14, 2017·Frontiers in Oncology·Ionica MasgrasAndrea Rasola
May 30, 2019·Frontiers in Oncology·Monica NeaguAristidis M Tsatsakis
Mar 30, 2017·International Journal of Biological Macromolecules·Monique Meyenberg Cunha de PaduaGuilhermina Rodrigues Noleto

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