Mitochondrial respiratory chain deficiency leads to overexpression of antioxidant enzymes

FEBS Letters
L BrambillaO Cantoni

Abstract

U937 cell growth in the presence of either chloramphenicol or ethidium bromide rapidly leads to respiratory deficiency. The novel finding of this report is that this response is paralleled by a specific increase in Se-dependent and independent glutathione peroxidase activities as well as of glutathione peroxidase and heme oxygenase mRNAs. Under the same experimental conditions, catalase activity and catalase mRNA do not show appreciable changes. These results can be explained by an increased formation of H2O2 at the early times of development of respiratory deficiency followed by induction of antioxidant enzymes.

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Citations

Jan 1, 2003·Journal of the American Aging Association·W Thomas Johnson, Samuel M Newman
Apr 16, 2010·Canadian Journal of Physiology and Pharmacology·Meghan L VerschoorGurmit Singh
Oct 8, 2004·Journal of Biochemistry and Molecular Biology·Roberto ScatenaBruno Giardina
Aug 7, 2013·The International Journal of Biochemistry & Cell Biology·Lorenzo PolimenoAntonio Francavilla
Jan 16, 2014·American Journal of Physiology. Endocrinology and Metabolism·Sarah Weksler-ZangenAnn Saada
Mar 8, 2002·American Journal of Physiology. Endocrinology and Metabolism·Akio KanazawaKihachiro Horiike
Nov 5, 2019·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Kyung-Ho Min, Wan Lee

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