PMID: 9179588May 1, 1997Paper

Mitochondrial respiratory chain features after gamma-irradiation

Free Radical Research
M BattinoG Lenaz

Abstract

Radiation provokes damage to DNA but also to membrane and protein structure. Radiolysis is a tool used very often in the study of free radical biological effects and of scavenger molecules effectiveness. Nitroimidazoles have been demonstrated to enhance the radiation effects on biological structures. The studies we have performed on isolated mitochondria irradiated, with and without nitroimidazoles, at a radiation dose equal to LD90, indicate that this treatment is not able to affect the structural and functional features investigated (ubiquinone-10, fatty acids, respiratory cytochrome levels or membrane fluidity and respiratory enzymatic activities), suggesting that an involvement of such externally produced radicals on membrane damage is unlikely. Moreover it was ascertained that the mitochondrial redox activities do not take part into the intracellular nitroimidazole reduction.

References

Oct 1, 1979·Biochemical Pharmacology·D A RowleyD I Edwards
Jan 1, 1978·Methods in Enzymology·Y Hatefi, D L Stiggall
Feb 1, 1990·International Journal of Radiation Biology·M E WattsI J Roberts
Jan 1, 1990·Free Radical Biology & Medicine·R E Beyer
Apr 1, 1989·International Journal of Radiation Oncology, Biology, Physics·M R StratfordM Woodcock
Sep 1, 1988·International Journal of Radiation Oncology, Biology, Physics·T H Wasserman
Apr 21, 1986·FEBS Letters·M BattinoG Lenaz
Sep 1, 1987·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·M E WattsM R Stratford

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Citations

Dec 28, 2002·Archives of Histology and Cytology·Yoichiro HosokawaToshihiko Yajima
Jan 14, 2000·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·M BattinoH Newman

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