Mitochondrial respiratory supercomplexes in mammalian cells: structural versus functional role.

Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte
Sabzali JavadovAmadou Ks Camara

Abstract

Mitochondria are recognized as the main source of ATP to meet the energy demands of the cell. ATP production occurs by oxidative phosphorylation when electrons are transported through the electron transport chain (ETC) complexes and develop the proton motive force across the inner mitochondrial membrane that is used for ATP synthesis. Studies since the 1960s have been concentrated on the two models of structural organization of ETC complexes known as "solid-state" and "fluid-state" models. However, advanced new techniques such as blue-native gel electrophoresis, mass spectroscopy, and cryogenic electron microscopy for analysis of macromolecular protein complexes provided new data in favor of the solid-state model. According to this model, individual ETC complexes are assembled into macromolecular structures known as respiratory supercomplexes (SCs). A large number of studies over the last 20 years proposed the potential role of SCs to facilitate substrate channeling, maintain the integrity of individual ETC complexes, reduce electron leakage and production of reactive oxygen species, and prevent excessive and random aggregation of proteins in the inner mitochondrial membrane. However, many other studies have challenged the prop...Continue Reading

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Citations

Jun 23, 2021·Nature Communications·Felix EversTaco W A Kooij
Aug 8, 2021·International Journal of Molecular Sciences·Minu ChaudhuriFidel Soto Gonzalez
Oct 9, 2021·Nature Reviews. Molecular Cell Biology·Irene Vercellino, Leonid A Sazanov

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Methods Mentioned

BETA
electrophoresis
electron cryotomography
electron microscopy
GTPase
acetylation

Software Mentioned

Mol
NGL Viewer

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