Mitochondrial response to calcium in the developing brain

Brain Research. Developmental Brain Research
Courtney L RobertsonGary Fiskum

Abstract

Developmental differences in mitochondrial content and metabolic enzyme activities have been defined, but less is understood about the responses of brain mitochondria to stressful stimuli during development. Cerebral mitochondrial response to high Ca(2+) loads after brain injury is a critical determinant of neuronal outcome. Brain mitochondria isolated from 16-18-day-old rats had lower maximal, respiration-dependent Ca(2+) uptake capacity than brain mitochondria isolated from adult rats in the presence of ATP at both a pH of 7.0 and 6.5. However, in the absence of ATP, immature brain mitochondria exhibited greater Ca(2+) uptake capacity at pH 7.0 and 6.5, indicating a greater resistance of immature brain mitochondria to Ca(2+)-induced dysfunction under conditions relevant to those that exist during acute ischemic and traumatic brain injury. Acidosis reduced the maximal Ca(2+) uptake capacity in both immature and adult brain mitochondria. Cytochrome c was released from both immature and adult brain mitochondria in response to Ca(2+) exposure, but was not affected by cyclosporin A, an inhibitor of the mitochondrial membrane permeability transition. Developmental changes in mitochondrial response to Ca(2+) loads may have important...Continue Reading

References

Aug 1, 1978·Archives of Biochemistry and Biophysics·K E Akerman
Jul 1, 1979·Archives of Biochemistry and Biophysics·R A Haworth, D R Hunter
May 1, 1975·Journal of Neurochemistry·D Holtzman, C L Moore
Jul 1, 1979·Stroke; a Journal of Cerebral Circulation·S RehncronaB K Siesjö
Apr 24, 1989·FEBS Letters·H Rottenberg, M Marbach
Feb 1, 1986·Journal of Neurochemistry·R von HanwehrB K Siesjö
Dec 1, 1987·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R E RosenthalS Sharpe
Jun 1, 1985·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·L HilleredB K Siesjö
Jan 1, 1973·Biology of the Neonate·D Holtzman, C L Moore
Oct 9, 1967·Biochimica Et Biophysica Acta·E C Weinbach, T Von Brand
Sep 1, 1984·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·L HilleredB K Siesjö
Jan 1, 1995·Pediatric Neurosurgery·L N SuttonR Zimmerman
Jan 1, 1996·Journal of Neurochemistry·S L Budd, D G Nicholls
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·A N MurphyG Fiskum
Sep 1, 1996·Experimental Brain Research·S NagaoM Ohkawa
Mar 14, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E GillandH Hagberg
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·D PohlC Ikonomidou
Mar 17, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A N MurphyM F Beal
Jan 6, 2000·Archives of Biochemistry and Biophysics·L K Kwong, R S Sohal
Sep 20, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·B R HuB K Siesjö
Jan 13, 2001·Brain Research. Developmental Brain Research·C WallinM Sandberg
Aug 3, 2001·The Journal of Biological Chemistry·B M PolsterG Fiskum
Oct 3, 2002·Journal of Neurochemistry·Anatoly A StarkovGary Fiskum
May 17, 2003·The Journal of Biological Chemistry·Christos ChinopoulosGary Fiskum
Oct 1, 1964·The Journal of Cell Biology·J W GREENAWALTA L LEHNINGER

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Citations

Nov 3, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Botros B Kostandy
Jan 25, 2014·Lancet Neurology·Henrik HagbergClaire Thornton
May 6, 2008·Journal of Neurotrauma·Paula A CaseyCourtney L Robertson
Jul 4, 2009·Journal of Child Neurology·Henrik Hagberg Xiaoyang Wang
Feb 27, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Xiaoyang WangHenrik Hagberg
Sep 1, 2006·Developmental Neuroscience·Patrick M Kochanek
Mar 26, 2016·Frontiers in Systems Neuroscience·Madhuvika MuruganSridhar S Kannurpatti
Dec 7, 2007·Journal of Neuroscience Research·Lucian SoaneGary Fiskum
Apr 4, 2007·Journal of Neurochemistry·Courtney L RobertsonGary Fiskum
Dec 9, 2008·Chemico-biological Interactions·Magdalena LabieniecCezary Watala
Apr 18, 2006·Experimental Gerontology·Peter SchönfeldGeorg Reiser
Jan 31, 2006·Free Radical Biology & Medicine·Klas Blomgren, Henrik Hagberg
Sep 1, 2006·Developmental Neuroscience·Courtney L RobertsonGary Fiskum
Oct 3, 2008·Neurosurgical Focus·Pavan Jagannathan, Jay Jagannathan
Dec 17, 2014·BMC Veterinary Research·Luis G FariaLuciane R Mesquita
Nov 18, 2017·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Patrick M KochanekRobert S B Clark
Mar 1, 2007·Current Opinion in Critical Care·Christopher C GizaAndranik Madikians
Mar 5, 2019·Experimental Neurology·Sheryl E ArambulaCourtney L Robertson
Aug 3, 2021·Frontiers in Neurology·Rebecka O SerpaMayumi L Prins

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