Mitochondrial selfish elements and the evolution of biological novelties

Current Zoology
Liliana MilaniMarco Passamonti

Abstract

We report the present knowledge about RPHM21, a novel male-specific mitochondrial protein with a putative role in the paternal inheritance of sperm mitochondria in the Manila clamRuditapes philippinarum, a species with doubly uniparental inheritance of mitochondria (DUI). We review all the available data onrphm21transcription and translation, analyze in detail its female counterpart, RPHF22, discuss the homology with RPHM21, the putative function and origin, and analyze their polymorphism. The available evidence is compatible with a viral origin of RPHM21 and supports its activity during spermatogenesis. RPHM21 is progressively accumulated in mitochondria and nuclei of spermatogenic cells, and we hypothesize it can influence mitochondrial inheritance and sexual differentiation. We propose a testable model that describes how the acquisition of selfish features by a mitochondrial lineage might have been responsible for the emergence of DUI, and for the evolution of separate sexes (gonochorism) from hermaphroditism. The appearance of DUI most likely entailed the invasion of at least 1 selfish element, and the extant DUI systems can be seen as resolved conflicts. It was proposed that hermaphroditism was the ancestral condition of b...Continue Reading

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Citations

Jan 18, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Fabrizio GhiselliLiliana Milani
May 24, 2019·Integrative and Comparative Biology·Fabrizio GhiselliLiliana Milani
Dec 4, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Liliana Milani, Fabrizio Ghiselli
Feb 3, 2018·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Elisabetta PunziMarco Passamonti
May 10, 2017·Scientific Reports·Davide GuerraSophie Breton
Apr 27, 2017·Molecular Biology and Evolution·Andrea PozziMarco Passamonti
Dec 1, 2016·Current Zoology·Anna K Lindholm, Tom A R Price
Sep 11, 2019·Integrative and Comparative Biology·Justin C HavirdGeoffrey E Hill
Sep 14, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Dave Speijer
Apr 6, 2021·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Fabrizio GhiselliJeffrey L Boore
May 5, 2021·Integrative and Comparative Biology·Fabrizio GhiselliLiliana Milani
Sep 18, 2021·Journal of Evolutionary Biology·Gerald P MaedaJustin C Havird

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