Mitochondrial stop and go: signals that regulate organelle movement

Science's STKE : Signal Transduction Knowledge Environment
Ian J Reynolds, Gordon L Rintoul

Abstract

In order to satisfy the metabolic and ion homeostasis demands of neurons, mitochondria must be transported to appropriate locations within cells. Although it is well established that much of this trafficking occurs on microtubules and, to a lesser extent, actin, the mechanisms by which the trafficking of mitochondria is controlled are poorly understood. A recent study by Chada and Hollenbeck shows that nerve growth factor halts the movement of mitochondria in axons by means of a mechanism that depends on activation of phosphatidylinositol 3-kinase. These studies provide important new insights into the mechanisms that regulate mitochondrial movement and control mitochondrial docking. These insights are critical to the understanding of the factors that control the distribution, location, and function of mitochondria in both healthy and injured neurons.

References

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Citations

Mar 29, 2006·Proceedings of the National Academy of Sciences of the United States of America·Robert W MahleyYadong Huang
Dec 23, 2008·Proceedings of the National Academy of Sciences of the United States of America·Masao SaotomeGyörgy Hajnóczky
Jun 16, 2009·American Journal of Physiology. Heart and Circulatory Physiology·John T FassettRobert J Bache
Apr 4, 2009·Experimental Neurology·Qian Cai, Zu-Hang Sheng
Sep 14, 2007·Trends in Cell Biology·Paola Pizzo, Tullio Pozzan
Dec 26, 2006·Progress in Neurobiology·Diane T W Chang, Ian J Reynolds
Dec 22, 2007·Glia·Guillaume AzariasJean-Yves Chatton
Mar 28, 2012·Biochimica Et Biophysica Acta·Gerald W Dorn
Dec 21, 2011·Biochimica Et Biophysica Acta·Stefan Grimm
Mar 15, 2012·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Kyu-Sang ParkClaes B Wollheim
Jul 27, 2006·Physiology·Kai S Dimmer, Luca Scorrano

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