Mitochondrial targeted fluorescent probe with AIE characteristics for bioimaging

Materials Science & Engineering. C, Materials for Biological Applications
Xiaodan LuRuiyuan Liu

Abstract

In this work, a new benzothiazole based mitochondrial tracker, Bth-Mito, is synthesized by with 2-benzothiazoleacetonitrile and 4-(diethylamino)-benzaldehyde. Bth-Mito is weakly fluorescent when dissolved in the good solvent but becomes highly emissive in poor solvents, showing a phenomenon of aggregation-induced emission. Bth-Mito shows the greatest potentials for bioimaging applications in view of low cytotoxicity and high photostability. Bth-Mito could penetrate cells to give stable green fluorescence, even after continuous irradiation, making it suitable candidate for time-lapse and long-term bioimaging application. Moreover, Bth-Mito could specifically localize in mitochondrial. Furthermore, in vivo imaging studies on nude mice have revealed that Bth-Mito could be used as optical imaging probe for in vivo imaging. Histological assessment of tissues treated with Bth-Mito also further confirmed the low toxicity and good biocompatibility of Bth-Mito.

Citations

Feb 7, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Wanfu XuRuiyuan Liu
Sep 24, 2019·Journal of Agricultural and Food Chemistry·Youwu HaoLiming Tao

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