Mitochondrial Targeting in Neurodegeneration: A Heme Perspective

Pharmaceuticals
Veronica FioritoEmanuela Tolosano

Abstract

Mitochondrial dysfunction has achieved an increasing interest in the field of neurodegeneration as a pathological hallmark for different disorders. The impact of mitochondria is related to a variety of mechanisms and several of them can co-exist in the same disease. The central role of mitochondria in neurodegenerative disorders has stimulated studies intended to implement therapeutic protocols based on the targeting of the distinct mitochondrial processes. The review summarizes the most relevant mechanisms by which mitochondria contribute to neurodegeneration, encompassing therapeutic approaches. Moreover, a new perspective is proposed based on the heme impact on neurodegeneration. The heme metabolism plays a central role in mitochondrial functions, and several evidences indicate that alterations of the heme metabolism are associated with neurodegenerative disorders. By reporting the body of knowledge on this topic, the review intends to stimulate future studies on the role of heme metabolism in neurodegeneration, envisioning innovative strategies in the struggle against neurodegenerative diseases.

References

Feb 1, 1995·Brain Research. Molecular Brain Research·S IkebeT Ozawa
Mar 12, 1999·Journal of Child Neurology·M Castro-GagoJ Eirís-Puñal
Sep 3, 1999·The Journal of Biological Chemistry·J AlamJ L Cook
Feb 14, 2002·Archives of Biochemistry and Biophysics·Hani AtamnaBruce N Ames
Feb 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Patrick B WalterBruce N Ames
Jul 9, 2002·Biochemical and Biophysical Research Communications·Maria Ankarcrona, Kjell Hultenby
Nov 6, 2002·Proceedings of the National Academy of Sciences of the United States of America·Hani AtamnaBruce N Ames
Mar 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jessica C GreeneLeo J Pallanck
Dec 4, 2003·Biochemical and Biophysical Research Communications·Takanori YokotaHidehiro Mizusawa
Jan 30, 2004·EMBO Reports·Takahiro TairaHiroyoshi Ariga
Feb 27, 2004·The Journal of Biological Chemistry·James J PalacinoJie Shen
May 5, 2004·The Journal of Biological Chemistry·Taejin Yoon, J A Cowan
Jul 21, 2004·Proceedings of the National Academy of Sciences of the United States of America·Hani Atamna, William H Frey
Sep 17, 2004·Muscle & Nerve·James W Albers, John K Fink
Jun 14, 2005·Brain Research. Molecular Brain Research·Amitabha SenguptaLi Zhang
Oct 14, 2005·Journal of Cellular Physiology·Wei SongHyman M Schipper
Oct 18, 2005·The Journal of Biological Chemistry·Wenbo Zhou, Curt R Freed
Oct 4, 2006·Proceedings of the National Academy of Sciences of the United States of America·Casey M ClementsJenny P-Y Ting
Nov 23, 2006·Journal of Alzheimer's Disease : JAD·Hani Atamna
Dec 22, 2006·The Journal of Nutrition·Hani AtamnaBruce N Ames
Aug 2, 2008·Proceedings of the National Academy of Sciences of the United States of America·Clemens R ScherzerMichael G Schlossmacher
Aug 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·Clement A GautierJie Shen
Nov 22, 2008·Biochemical Society Transactions·Ilaria PelizzoniFranca Codazzi
Nov 26, 2008·The Journal of Cell Biology·Derek NarendraRichard J Youle
Dec 5, 2008·Nature·Olga Martins de Brito, Luca Scorrano
Dec 20, 2008·The Journal of Biological Chemistry·Xueshan GaoJohn W Eaton

❮ Previous
Next ❯

Citations

Sep 27, 2019·CNS Drugs·Niels BergslandRobert Zivadinov
Jan 15, 2020·Current Pharmaceutical Design·Octavio Binvignat, Jordi Olloquequi
Dec 11, 2019·Pharmaceuticals·Raffaella GozzelinoPaolo Arosio
Feb 6, 2020·Frontiers in Oncology·Veronica FioritoEmanuela Tolosano
Oct 26, 2018·Frontiers in Neuroscience·Deborah ChiabrandoEmanuela Tolosano
Feb 13, 2019·International Journal of Molecular Sciences·Michiel Van BulckJose A Morales-Garcia
Apr 4, 2019·Frontiers in Oncology·Francesca DestefanisEmanuela Tolosano
May 30, 2020·International Journal of Molecular Sciences·Deborah ChiabrandoEmanuela Tolosano
Feb 6, 2021·Neuroscience and Biobehavioral Reviews·Deborah ChiabrandoEmanuela Tolosano
Jul 1, 2020·CNS & Neurological Disorders Drug Targets·Maria GevezovaMichael Maes

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.