Mitochondrial UPR: A Double-Edged Sword

Trends in Cell Biology
Ye TianAndrew Dillin

Abstract

The mitochondrial unfolded protein response (UPR(mt)) promotes the recovery of dysfunctional mitochondria. Surprisingly, UPR(mt) activation inadvertently maintains and propagates the deleterious mtDNA in a heteroplasmic Caenorhabditis elegans strain, with detrimental consequences. This study extends our understanding of the UPR(mt) and provides a possible therapeutic target for diseases associated with mtDNA mutations.

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Citations

Mar 17, 2018·Genes·Corina T Madreiter-SokolowskiWolfgang F Graier
Nov 6, 2018·Reproductive Biology and Endocrinology : RB&E·Li LiQing-Yuan Sun
Nov 7, 2019·International Journal of Molecular Sciences·Joana SantiagoMargarida Fardilha
Sep 14, 2017·Oxidative Medicine and Cellular Longevity·Osvaldo C MoreiraJavier González-Gallego
Jul 26, 2018·Frontiers in Genetics·Shauna HillHolly Van Remmen
Nov 30, 2018·Journal of Cellular Physiology·Yitian ZhengXianhe Lin
Oct 12, 2018·Nature Reviews. Molecular Cell Biology·Lorenzo GalluzziGuido Kroemer
Apr 13, 2018·Frontiers in Cell and Developmental Biology·Sylvie Callegari, Sven Dennerlein

Related Concepts

Metazoa
DNA, Mitochondrial
Mitochondria
Oxidative Phosphorylation
Caenorhabditis elegans
Unfolded Protein Response
DNA, Mitochondrial
Mitochondria
Caenorhabditis elegans
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