Mitochondrial UPR: A Double-Edged Sword

Trends in Cell Biology
Ye TianAndrew Dillin


The mitochondrial unfolded protein response (UPR(mt)) promotes the recovery of dysfunctional mitochondria. Surprisingly, UPR(mt) activation inadvertently maintains and propagates the deleterious mtDNA in a heteroplasmic Caenorhabditis elegans strain, with detrimental consequences. This study extends our understanding of the UPR(mt) and provides a possible therapeutic target for diseases associated with mtDNA mutations.


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Related Concepts

DNA, Mitochondrial
Oxidative Phosphorylation
Caenorhabditis elegans
Unfolded Protein Response
DNA, Mitochondrial
Caenorhabditis elegans
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