Mitochondriosis of the hepatocytic cytoplasm in rachitic rat liver after calcitonin-treatment (a cytophotometric and morphometric study).

Beiträge Zur Pathologie
U N RiedeW Sandritter

Abstract

A calcium-rich rachitogenic vitamin-D deficiency and additional doses of calcitonin cause serious changes in cell structure and metabolism, which can be demonstrated by cytophotometry and morphometry. The experiments were made with 9 male juvenile Wistar rats. 6 animals were kept on a vitamin-D deficient diet for 6 weeks and 3 of these animals got injections with salmon-calcitonin S.C. during the last 14 days every second day. The remaining 3 animals, fed with altromin-R standard diet were kept for control purposes only. The morphometric analysis of the liver parenchymal cells was based on the statements by Weibel and the cytophotometric examinations were made according to the Sandritter technique. As a consequence of the altered metabolic condition a great volume reduction of cells and cell nuclei is found in the animals with vitamin-D deficiency, which were treated with calcitonin. In comparison with the control animals the hepatocytes show hardly any tetraploid nuclei, which points to an inhibited polyploidization. The cytoplasm shows an oncocytic transformation with megamitochondria. As reason for this mitochondriopathy an extreme and abnormal growth as well as a mutation of the mitochondrial genom are under discussion. Fur...Continue Reading

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Citations

Sep 1, 1976·Beiträge Zur Pathologie·G Kiefer, W Sandritter
Dec 1, 1980·Experimental and Molecular Pathology·U N RiedeW Sandritter
Jan 1, 1983·Critical Reviews in Toxicology·U Riede, G W Moore

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