Mitoferrin is essential for erythroid iron assimilation

Nature
George C ShawBarry H Paw

Abstract

Iron has a fundamental role in many metabolic processes, including electron transport, deoxyribonucleotide synthesis, oxygen transport and many essential redox reactions involving haemoproteins and Fe-S cluster proteins. Defective iron homeostasis results in either iron deficiency or iron overload. Precise regulation of iron transport in mitochondria is essential for haem biosynthesis, haemoglobin production and Fe-S cluster protein assembly during red cell development. Here we describe a zebrafish mutant, frascati (frs), that shows profound hypochromic anaemia and erythroid maturation arrest owing to defects in mitochondrial iron uptake. Through positional cloning, we show that the gene mutated in the frs mutant is a member of the vertebrate mitochondrial solute carrier family (SLC25) that we call mitoferrin (mfrn). mfrn is highly expressed in fetal and adult haematopoietic tissues of zebrafish and mouse. Erythroblasts generated from murine embryonic stem cells null for Mfrn (also known as Slc25a37) show maturation arrest with severely impaired incorporation of 55Fe into haem. Disruption of the yeast mfrn orthologues, MRS3 and MRS4, causes defects in iron metabolism and mitochondrial Fe-S cluster biogenesis. Murine Mfrn rescue...Continue Reading

References

May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·R BalzanJ V Bannister
Oct 4, 2000·Nature Genetics·A Nasevicius, S C Ekker
Sep 5, 2001·Current Opinion in Genetics & Development·A B Cantor, S H Orkin
Jan 5, 2002·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Fang-Yuan LiCatharina Larsson
Feb 15, 2002·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Q Z LiJ X She
Apr 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Susan E LyonsP Paul Liu
Aug 20, 2002·Nature Genetics·Marjorie J RosenbergLeslie G Biesecker
Aug 7, 2003·The Journal of Biological Chemistry·Ulrich MühlenhoffGerlinde Wiesenberger
Apr 28, 2004·Cell·Matthias W HentzeNancy C Andrews
May 27, 2004·The Journal of Biological Chemistry·Liangtao Li, Jerry Kaplan
Aug 18, 2004·Current Opinion in Hematology·Ebrahim Shafizadeh, Barry H Paw
Mar 9, 2005·Trends in Biochemical Sciences·Roland Lill, Ulrich Mühlenhoff
Mar 16, 2005·The Journal of Biological Chemistry·Yan ZhangAndrew Dancis
Apr 2, 2005·Nature Reviews. Molecular Cell Biology·Tracey A Rouault, Wing-Hang Tong

❮ Previous
Next ❯

Citations

Oct 14, 2008·Genes & Nutrition·G CairoS Recalcati
Dec 10, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Des R RichardsonYohan Suryo Rahmanto
Sep 8, 2006·Wiener klinische Wochenschrift·Manfred Nairz, Günter Weiss
Feb 8, 2011·Journal of Neural Transmission·Esther G Meyron-HoltzLyora A Cohen
Apr 10, 2010·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Sophie E BoddingtonHeike E Daldrup-Link
Jun 26, 2012·Biochemistry·Nema D JhurryPaul A Lindahl
Jun 19, 2012·Biochemistry·Kostas PantopoulosL Devireddy
Jun 16, 2009·Chemical Reviews·Aaron Atkinson, Dennis R Winge
Sep 22, 2009·Chemical Reviews·Scott Severance, Iqbal Hamza
May 26, 2011·Nature Communications·Khurram BashirNaoko K Nishizawa
Apr 22, 2009·Molecular BioSystems·Valerie HowerSuzy V Torti
May 25, 2010·Proceedings of the National Academy of Sciences of the United States of America·Des R RichardsonPrem Ponka
Jun 30, 2009·The Journal of Biological Chemistry·Amornrat NaranuntaratValeria C Culotta
Sep 22, 2009·The Journal of Biological Chemistry·Ruth E DavidsonJames D Reid
Oct 23, 2010·The Journal of Biological Chemistry·Gregory A Hunter, Gloria C Ferreira
Jul 3, 2008·The Journal of Biological Chemistry·Gregory A HunterGloria C Ferreira
Jun 5, 2010·The Journal of Biological Chemistry·Iman J SchultzIqbal Hamza
May 7, 2011·Antioxidants & Redox Signaling·Michael Li-Hsuan HuangDes R Richardson
Mar 13, 2012·Current Opinion in Hematology·Jacky ChungBarry H Paw
Mar 3, 2009·Seminars in Dialysis·Theodoros EleftheriadisIoannis Stefanidis
Apr 7, 2010·Molecular Interventions·Dean P JonesNeil Kaplowitz
Jun 25, 2008·Molecular and Cellular Biology·Oliver StehlingRoland Lill
Jan 21, 2011·Molecular and Cellular Biology·Julio D AmigoBarry H Paw
Dec 17, 2008·Molecular and Cellular Biology·Prasad N ParadkarJerry Kaplan
Jan 12, 2007·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·P CourvilleM F M Cellier
Mar 21, 2007·Annual Review of Neuroscience·Erik Madsen, Jonathan D Gitlin
Oct 4, 2006·Annual Review of Physiology·Nancy C Andrews, Paul J Schmidt
Jul 9, 2008·Blood·Nancy C Andrews
Feb 12, 2011·Blood·Marie-Berengere TroadecJerry Kaplan
Jan 11, 2007·BMC Genomics·Robert GeislerChristiane Nüsslein-Volhard
Dec 31, 2011·Genome Medicine·Corey S MartinLeonard I Zon

❮ Previous
Next ❯

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.