PMID: 9172385Jul 1, 1997Paper

Mitogen-activated protein kinase cascades and the signaling of hyperosmotic stress to immediate early genes

Comparative Biochemistry and Physiology. Part A, Physiology
D M Cohen

Abstract

Among prokaryotes and lower eukaryotes, the threat of exposure to hyperosmotic stress is ubiquitous. Among higher eukaryotes, in contrast, only specific tissues are routinely exposed to marked hypertonicity. The mammalian renal medulla, the prototypical example, is continually subjected to an elevated solute concentration as a consequence of the renal concentrating mechanism. Until recently, the investigative focus has concerned the effects of diverse solutes on the regulation of genes essential for the adaptive accumulation of osmotically active organic solutes. Recent and sweeping developments elucidating the molecular mechanisms underlying stress signaling to the nucleus have focused interest on earlier events in the response to hyperosmotic stress. Such events include the transcriptional activation and post-translational modification of transcriptional activating proteins, a large subset of which represent the protein products of so-called immediate early genes. This review highlights developments in the understanding of stress signaling in general and hypertonic stress signaling in particular in both yeast and higher eukaryotic models. The relationship between hyperosmotic stress signaling and the transcription and activat...Continue Reading

References

Sep 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S UchidaJ S Handler
Mar 1, 1992·Molecular and Cellular Biology·R H ChenJ Blenis
Mar 11, 1992·The American Journal of Physiology·F L SmardoA Garcia-Perez
Oct 1, 1991·The American Journal of Physiology·D M CohenS R Gullans
Jan 1, 1991·Annual Review of Microbiology·L N Csonka, A D Hanson
Oct 1, 1991·Physiological Reviews·A Garcia-Perez, M B Burg
Jul 1, 1990·Molecular and Cellular Biology·P LemaireP Charnay
Dec 1, 1990·Journal of the American Society of Nephrology : JASN·V P Sukhatme
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·P S ChangelianJ Milbrandt
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·B Christy, D Nathans
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·P LemaireP Charnay
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·B A ChristyD Nathans
Mar 19, 1993·Science·J L BrewsterM C Gustin
Oct 25, 1994·Proceedings of the National Academy of Sciences of the United States of America·J D FerrarisA García-Pérez
Aug 5, 1994·Science·Z Galcheva-GargovaR J Davis
May 12, 1994·Nature·J M KyriakisJ R Woodgett
Feb 1, 1994·Current Opinion in Genetics & Development·C J Marshall
Oct 22, 1993·Science·I M Ota, A Varshavsky

❮ Previous
Next ❯

Citations

Jul 1, 1997·Comparative Biochemistry and Physiology. Part A, Physiology·R Gilles
Feb 23, 1999·Clinical and Experimental Pharmacology & Physiology·D M Cohen
Sep 26, 2006·Nucleic Acids Research·Dominique A Glauser, Werner Schlegel
Apr 7, 2009·Biological Reviews of the Cambridge Philosophical Society·Karin S KassahnM Julian Caley
Sep 11, 2007·Annals of the Rheumatic Diseases·G SchettG Firestein
Feb 7, 2016·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Linhong JiangPing Ji
May 18, 2004·The Journal of Physiology·Zebo Huang, Alan Tunnacliffe
Oct 14, 2000·Neurobiology of Learning and Memory·D F Clayton
Aug 28, 2004·Diabetes Research and Clinical Practice·Mark CukiernikSubrata Chakrabarti
Nov 21, 2001·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·T V Hansen, F C Nielsen
Jun 3, 2016·The Journal of Experimental Biology·Ken M JeffriesNann A Fangue
Feb 22, 2003·Physiological Genomics·Michael G EdwardsTomas A Prolla
Nov 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·T PurvesD R Tomlinson
Feb 12, 1998·The American Journal of Physiology·Z Zhang, D M Cohen
Oct 2, 2007·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Yukio Niimura, Ken-ichi Nagai

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.