Mitogen-activated protein kinase is required for the behavioural desensitization that occurs after repeated injections of angiotensin II.

Experimental Physiology
Peter J Vento, Derek Daniels

Abstract

Angiotensin II (Ang II) acts on central angiotensin type 1 (AT(1)) receptors to increase water and saline intake. Prolonged exposure to Ang II in cell culture models results in a desensitization of the AT(1) receptor that is thought to involve receptor internalization, and a behavioural correlate of this desensitization has been shown in rats after repeated central injections of Ang II. Specifically, rats given repeated injections of Ang II drink less water than control animals after a subsequent test injection of Ang II. In the same conditions, however, repeated injections of Ang II have no effect on Ang II-induced saline intake. Given earlier studies indicating that separate intracellular signalling pathways mediate Ang II-induced water and saline intake, we hypothesized that the desensitization observed in rats may be incomplete, leaving the receptor able to activate mitogen-activated protein (MAP) kinases (ERK1/2), which play a role in Ang II-induced saline intake without affecting water intake. In support of this hypothesis, we found no difference in MAP kinase phosphorylation after an Ang II test injection in rats given prior treatment with repeated injections of vehicle, Ang II or Sar(1),Ile(4),Ile(8)-Ang II (SII), an An...Continue Reading

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Dec 24, 2011·Physiology & Behavior·Peter J VentoDerek Daniels

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Citations

Aug 30, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·George E FarmerJ Thomas Cunningham
Oct 31, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jessica SantolloDerek Daniels

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