Mitogen-Activated Protein Kinase (MAPK): New Insights in Breast Cancer

Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer
Huanyu LuXingsong Tian

Abstract

The eukaryotic cell cycle via mitogen-activated protein kinase (MAPK) has been considered as an effective signaling cascade pathway for anticancer therapy. In addition to the MAPK signaling pathway, the Rat Sarcoma Virus (Ras)/Rapidly Accelerated Fibrosarcoma (Raf)/MAPK-ERK kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway is a signaling cascade that has a crucial role to play in cell survival and development of cancer, especially breast cancer. Novel drugs and clinical trials need to be investigated, taking into consideration the already studied genetic defects related to genesis of tumors in certain populations. The present review provides novel insights into current anticancer treatments involving the MAPK pathway.

Citations

Dec 1, 2019·Drug Development Research·Mohammad AltamishGaurav Gupta
Feb 12, 2020·Journal of Biochemical and Molecular Toxicology·Jin-Ling FuGuang Shi
Mar 20, 2020·Future Medicinal Chemistry·Shelly Pathania, Ravindra K Rawal
Jul 30, 2020·Stem Cells International·Mengting YangQingli Bie
Dec 12, 2019·Drug Development Research·Zhaoji LuanLina Shi
Jun 22, 2019·BioMed Research International·Heshu LiuGuangyu An

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