Mitogen-activated protein kinase signaling is involved in nonylphenol-induced proinflammatory cytokines secretion by BV2 microglia

Journal of Applied Toxicology : JAT
Weijia GuJie Chen

Abstract

Microglia (MG) are the key cells involved in the innate immune response in the central nervous system, and their activation has been linked to inflammation and neurotoxicity by the production of proinflammatory cytokines. Recently, researchers have found that nonylphenol (NP), a ubiquitous endocrine disrupting chemical, could impair neurodevelopment and cognitive memory performance. However, whether NP affects the inflammatory responses of MG remains to be elucidated. The aim of this study was to explore the effects of NP on the inflammatory responses of BV2 MG and the underlying mechanisms. Our results showed that NP increased the secretion of interleukin (IL)-6 and IL-1β in BV2 MG. Increased phosphorylation of Akt, JNK and p38 mitogen-activated protein kinase and decreased phosphorylation of ERK were observed in NP-treated MG. The inflammatory transcription factor activator protein 1 was also activated in NP-treated BV2 MG. These results suggest that NP may activate Akt/mitogen-activated protein kinase/activator protein 1 signaling in MG and subsequently increase IL-6 and IL-1β secretion.

References

Nov 13, 1998·Bulletin of Environmental Contamination and Toxicology·M A ManzanoJ M Quiroga
May 12, 2000·Critical Care Medicine·T ObataM B Yaffe
Mar 21, 2001·Cellular Signalling·M Guha, N Mackman
Feb 22, 2002·Glia·Amy RasleyIan Marriott
Jun 14, 2002·Biochemical and Biophysical Research Communications·Ho Jin YouHye Gwang Jeong
Sep 27, 2003·Neoplasia : an International Journal for Oncology Research·Amy L SilversG Timothy Bowden
May 15, 2007·Current Opinion in Neurology·Andis KlegerisPatrick L McGeer
Sep 11, 2007·Annals of the Rheumatic Diseases·G SchettG Firestein
May 5, 2009·Chemosphere·M J Lopez-EspinosaN Olea
Mar 3, 2010·Environmental Health Perspectives·Nicoletta BechiLuana Paulesu
Jul 21, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Asli KorkmazNurhayat Barlas
Oct 6, 2010·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Xu JieLi Yan
Nov 16, 2010·Chemosphere·Fulvio FerraraEnzo Funari
Feb 23, 2011·International Journal of Molecular Sciences·Zhen MaoYan-Qiu Zhang
Mar 2, 2012·Neuron Glia Biology·José L Marín-TevaJulio Navascués
Nov 14, 2012·Journal of Applied Toxicology : JAT·Tin-Tin Win-ShweHirohisa Takano
Dec 25, 2012·Trends in Neurosciences·Hiroaki WakeJunichi Nabekura
Sep 3, 2013·Neuroscience·H WeiX Li
Feb 21, 2014·Pharmacological Reports : PR·Małgorzata Kajta, Anna K Wójtowicz
Aug 17, 2014·Biochemical and Biophysical Research Communications·Yanzhen LiuMeiying Xu
Mar 1, 2015·Environmental Research·Emily L RoenFrederica P Perera
Dec 9, 2015·The Journal of Steroid Biochemistry and Molecular Biology·E LitwaM Kajta
Oct 21, 2016·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Eunhee Kim, Sunghee Cho
Jun 18, 2017·Life Sciences·Daniela Recabarren, Marcelo Alarcón

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