Mitogen-activated protein kinase-signaling stimulates Müller glia to proliferate in acutely damaged chicken retina.

Glia
Andy J FischerWilliam Tuten

Abstract

Müller glia in the mature retina have the capacity to become progenitor-like cells in a many different vertebrate classes. The cell-signaling pathways that control the ability of mature Müller glia to become progenitor-like cells remain uncertain. The purpose of this study was to investigate the roles of the Mitogen-Activated Protein Kinase (MAPK) pathway in regulating the activity of Müller glia in the chicken retina. In response to acute retinal damage, we found that Müller glia accumulated phosphorylated ERK1/2 and phospho-CyclicAMP Response Element Binding-protein (pCREB), and transiently expressed immediate early genes, cFos and Egr1, that are known to be downstream of MAPK-signaling. Egr1 and pCREB were normally expressed by retinal progenitors in the circumferential marginal zone (CMZ), whereas cFos and pERK1/2 were not. In addition, small molecule inhibitors of MEK (UO126) and the FGF-receptor (SU5402) suppressed the proliferation of Müller glia-derived progenitor-like cells. These inhibitors suppressed the accumulation of Egr1 and pCREB, whereas levels of cFos were unaffected in the glial cells. These findings suggest that Egr1 and pCREB are downstream of the signaling cascade activated by FGF-receptors and ERK1/2. Fur...Continue Reading

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Citations

Nov 23, 2010·Molecular Neurobiology·Andy J Fischer, Rachel Bongini
Nov 27, 2009·Stem Cells and Development·Francisco J RiveraLudwig Aigner
Jun 23, 2010·PloS One·Andy J FischerMelissa A Scott
Feb 14, 2013·PloS One·Liyun ZhangYuk Fai Leung
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Feb 26, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kanika GhaiAndy J Fischer
Feb 28, 2015·Vision Research·Maria K WalkerNathan Doble
May 24, 2014·Cell Death & Disease·A SahabogluF Paquet-Durand
Aug 23, 2012·Journal of Biomedicine & Biotechnology·Yuki Muranishi, Takahisa Furukawa
Apr 15, 2009·Neuromolecular Medicine·Thomas LangmannBernhard H F Weber
Sep 29, 2011·Current Eye Research·Kenneth HeadingtonNathan Doble
Jul 25, 2012·Experimental Eye Research·Eric R RitcheyAndy J Fischer
Jun 15, 2012·Experimental Eye Research·Eric R RitcheyAndy J Fischer
Oct 15, 2013·Journal of Neurochemistry·Bernardo StutzFernando G de Mello
Jul 18, 2009·Glia·Eric McCoy, Harald Sontheimer
Jul 16, 2013·Experimental Eye Research·Donika GallinaAndy J Fischer
Oct 6, 2012·The Biochemical Journal·Karla Barbosa-SabaneroKatia Del Rio-Tsonis
May 9, 2014·Experimental Eye Research·Andy J FischerHeithem M El-Hodiri
Sep 10, 2013·Experimental Eye Research·S MétraillerR Roduit
Sep 13, 2013·Experimental Eye Research·Andy J FischerHeithem M El-Hodiri
Aug 19, 2014·Survey of Ophthalmology·Yi SunL Jay Katz
May 4, 2010·The Journal of Comparative Neurology·Jennifer StankeAndy J Fischer
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Jun 5, 2014·Nature Reviews. Neuroscience·Daniel Goldman
Dec 15, 2015·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Annaïg HamonMuriel Perron
Dec 15, 2015·Developmental Neurobiology·Donika GallinaAndy J Fischer

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