PMID: 6981654Jul 1, 1982Paper

Mitogen-induced maturation of chronic lymphocytic leukemia B lymphocytes

Journal of Clinical Immunology
P GuglielmiM Seligmann

Abstract

Peripheral blood lymphocytes from eight patients with untreated B-derived chronic lymphocytic leukemia (CLL) (only one had a serum monoclonal immunoglobulin) were stimulated by Nocardia, phytohemagglutinin, and pokeweed mitogen. This stimulation resulted in the occurrence in all but one case of large cytoplasmic immunoglobulin-containing cells with a predominantly lymphoblastic (six cases) or plasmacytic (one case) appearance. These blast cells contained the same immunoglobulin chains as those of the surface immunoglobulins on fresh lymphocytes except for delta chains that were not found by cytoplasmic immunofluorescence. In three cases, intracytoplasmic immunoglobulin inclusions that were present in both small lymphocytes and stimulated blast cells provided further evidence of the differentiation of the leukemic clone. In another case, both small leukemic B lymphocytes and large B blast cells expressed in vitro a receptor for sheep erythrocytes. A switch from IgM to IgG synthesis was observed in this patients, whose cells showed the strongest response to the activators. The most effective activator was Nocardia, then phytohemagglutinin, whereas an effect of pokeweed mitogen was observed only when the fresh lymphocytes containe...Continue Reading

References

Dec 2, 1976·The New England Journal of Medicine·F P Siegal
Aug 23, 1979·The New England Journal of Medicine·G GahrtonA G Bird
Jan 1, 1979·Scandinavian Journal of Immunology·K H RobèrtE Möller
Feb 1, 1978·European Journal of Immunology· LêthibichthuyJ Brochier
Dec 1, 1978·The Journal of Experimental Medicine·S M FuS R Harris
Mar 1, 1976·Journal of the National Cancer Institute·J C BrouetM Seligmann
Nov 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·S M FuH G Kunkel
Jan 1, 1982·British Journal of Haematology·P GuglielmiM T Daniel
May 1, 1980·British Journal of Cancer·J PiersonM Virji
Jan 1, 1981·Scandinavian Journal of Immunology·P Guglielmi, J L Preud'homme
Jul 10, 1980·Nature·P GuglielmiG Flandrin
Dec 1, 1980·The Journal of Experimental Medicine·F K StevensonA L Tutt

❮ Previous
Next ❯

Citations

May 1, 1994·International Journal of Immunopharmacology·R Barot-Ciorbaru
May 1, 1985·The Journal of Experimental Medicine·O LantzJ C Brouet
Feb 1, 1989·Scandinavian Journal of Immunology·R Barot-CiorbaruC Carnaud

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.