Mitogen stimulation of cerebrospinal fluid lymphocytes in aseptic meningitis
The cell responses to different polyclonal lymphocyte activating substances were studied in 15 patients with aseptic meningitis by analysis of lymphocyte proliferation. The in vitro response to phytohaemagglutinin (PHA), concanavalin A (Con A) and poke weed mitogen (PWM) was investigated in blood and CSF lymphocytes simultaneously. The blood lymphocytes responded stronger than the corresponding number of CSF lymphocytes. These cells were, however, always capable of a response, suggesting that they were immunologically competent. No predominance of either PHA or Con A populations of T lymphocytes could be demonstrated in CSF compared to blood by this technique. When culture conditions were changed from the optimal cell or mitogen concentrations, the decrease in proliferation of the CSF lymphocytes was more pronounced than that of blood lymphocytes.
Activation of T and B lymphocytes in vitro: presence of beta2-microblobulin determinants on allogeneic effect factor
Autoradiographic studies of cultures of cerebrospinal fluid lymphocytes in nonsuppurative meningitis
Cell-mediated immunity in humans during viral infection. I. Effect of rubella on dermal hypersensitivity, phytohemagglutinin response, and T lymphocyte numbers.
Cytokinetic studies on the orgin of cells of the cerebrospinal fluid. With a contribution to the cytogenesis of the leptomeningeal mesenchyme
Specificity of the inflammatory response in viral encephalitis. I. Adoptive immunization of immunosuppressed mice infected with Sindbis virus
Correlation between the potency of mumps virus skin test antigen and cutaneous delayed hypersensitivity
Isoelectric focusing of CSF proteins in known or probable infectious neurological diseases and the Guillain-Barré syndrome
Virus-reactive and autoreactive T cells are accumulated in cerebrospinal fluid in multiple sclerosis
Comparison of the response to phytohemagglutinin, of peripheral blood mononuclear cells and cerebrospinal fluid lymphocytes in multiple sclerosis and other neurological diseases. Determination of the frequency of the precursor cells by a limiting dilution analysis
Demonstration of cerebrospinal fluid lymphocytes sensitized against virus antigens in mumps meningitis
Specific in vitro IgG subclass synthesis and lymphocyte proliferation responses in herpes virus encephalitis
Sensitization of cerebrospinal fluid and peripheral blood lymphocytes to myelin basic protein in multiple sclerosis
Cerebrospinal fluid and serum immunoglobulins and antibody titers in mumps meningitis and aseptic meningitis of other etiology.
CSF & Lymphatic System
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