PMID: 629156Jan 1, 1978Paper

Mitogen stimulation of cerebrospinal fluid lymphocytes in aseptic meningitis

Acta Neurologica Scandinavica
A Frydén, H Link

Abstract

The cell responses to different polyclonal lymphocyte activating substances were studied in 15 patients with aseptic meningitis by analysis of lymphocyte proliferation. The in vitro response to phytohaemagglutinin (PHA), concanavalin A (Con A) and poke weed mitogen (PWM) was investigated in blood and CSF lymphocytes simultaneously. The blood lymphocytes responded stronger than the corresponding number of CSF lymphocytes. These cells were, however, always capable of a response, suggesting that they were immunologically competent. No predominance of either PHA or Con A populations of T lymphocytes could be demonstrated in CSF compared to blood by this technique. When culture conditions were changed from the optimal cell or mitogen concentrations, the decrease in proliferation of the CSF lymphocytes was more pronounced than that of blood lymphocytes.

References

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Citations

Oct 1, 1979·Journal of the Neurological Sciences·J KinnmanE Norrby
Feb 1, 1983·Journal of the Neurological Sciences·M ReunanenA Salmi
Jan 1, 1979·Scandinavian Journal of Immunology·S Kam-HansenE Möller
Jan 1, 1981·Scandinavian Journal of Immunology·J KinnmanH Link
Apr 1, 1982·Scandinavian Journal of Immunology·M ReunanenA Salmi

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