[Mitogenic activity of melanoma extracts in leucocyte cultures (author's transl)].

Archives of Dermatological Research
G Lischka

Abstract

From a mixed cell suspension of five primary melanomas an aqueous sterile extract was made and added to homologue leucocyte cultures of eight melanoma patients and seven controls. The extract had a blastogenic and mitogenic effect in all cultures. There was no significant difference between the responses of patients and controls. In experiments with an equally prepared extract of normal skin, added to homologue leucocyte cultures of nine persons, none but one had a positive reaction. This indicates, that the motigenic principle of the melanoma extract is not related to the histocompatibility antigen nor caused by chemical or bacterial contamination of the primary cell suspensions. It seems to be derived from the cytoplasmic fraction of melanoma cells. Other experiments to solve the problem were impossible because of lack of material. There are several reports in the literature which by using different methods indicate, that there might be an immunological reaction to melanoma associated principles in healthy persons, too.

References

Aug 13, 1970·The New England Journal of Medicine·U W JehnM Skinner
Jan 15, 1971·International Journal of Cancer. Journal International Du Cancer·I HellströmG A Warner
Jan 1, 1972·Archiv Für Dermatologische Forschung·G Burg, O Braun-Falco
Dec 1, 1972·The British Journal of Dermatology·R M MackieA J Cochran
Sep 15, 1971·International Journal of Cancer. Journal International Du Cancer·G FossatiU Veronesi
Mar 23, 1968·Nature·D L MannS G Nathenson
Feb 1, 1967·Acta Medica Scandinavica·M Soborg, G Bendixen
Jan 15, 1967·International Journal of Cancer. Journal International Du Cancer·I Hellström

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