Mitogenic and antigenic properties of group A streptococcal M protein preparations

Immunobiology
H KnöllJ Havlicek

Abstract

The separation of a mitogenic substance in M protein preparations of Streptococcus pyogenes, type 1 and type 12, is described. The isolation was achieved by gel chromatography on Biogel A 0.5 m, and by immunochromatography on immobilized type specific antibodies. In the delayed cutaneous hypersensitivity test the immunochromatography purified M 1 protein caused erythema but no unspecific mitogenicity could be found by lymphocyte transformation test. In neutralization experiments the mitogenic activity of M protein preparations was specifically inhibited by anti-erythrogenic toxin antisera.

References

Apr 1, 1969·The Journal of Experimental Medicine·A TarantaF Quagliata
Jun 15, 1973·Experientia·V Hríbalová, M Pospísil

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Citations

May 1, 1995·Medical Microbiology and Immunology·B FleischerK H Schmidt
Jun 1, 1985·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section B, Microbiology·O KühnemundW Köhler

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