PMID: 6982332Sep 1, 1982Paper

Mitogenic responses of peripheral blood lymphocytes from pregnant and ovariectomized heifers and their modulation by serum

Journal of Reproductive Immunology
R C Manak

Abstract

Lymphocyte-enriched peripheral blood mononuclear leukocytes (PBL) were obtained concurrently from a group of gestating heifers at intervals throughout pregnancy and from a group of ovariectomized heifers of the same age. The cells were suspended in media containing either ovariectomized heifer sera or sera from heifers at the homologous stage of pregnancy, and incubated with various concentrations of Concanavalin A (Con A), Pokeweed Mitogen (PWM) or phytohemagglutinin (PHA). Their mitotic response to the lectins was then assessed by determining [3H]thymidine incorporation into DNA. The response of PBL from pregnant heifers gradually increased as pregnancy progressed when compared with the response of PBL from ovariectomized heifers. The increased response continued until parturition but was not detectable at two weeks postpartum. This pattern was demonstrated for all three mitogens, although the effect was more pronounced with Con A and PWM and PHA. Sera from mid-trimester pregnant animals suppressed the mitotic response of PBL from both pregnant and ovariectomized heifers. This suppressive effect was not detectable in sera from pregnant animals in early or late stages of pregnancy.

References

Mar 1, 1978·British Journal of Obstetrics and Gynaecology·G GarewalA N Gupta
Mar 1, 1976·Proceedings of the Society for Experimental Biology and Medicine·H A Tucker, R P Wetteman
Dec 16, 1972·Lancet·M R Harrison
Aug 1, 1974·Journal of Reproduction and Fertility·H Karg, D Schams
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Jan 1, 1968·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·H Host
May 1, 1981·Journal of Reproductive Immunology·M Miyasaka, P McCullagh
Aug 15, 1980·Cellular Immunology·W A Weppner, J H Coggin
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May 1, 1964·Transplantation·R C GOODLIN, L A HERZENBERG
Jan 1, 1964·Methods in Medical Research·R MISHELL

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Citations

May 1, 1994·Tropical Animal Health and Production·P H AmerasingheS T Fernando
Dec 1, 1986·Journal of Reproductive Immunology·A J WinterW L Castleman
Jul 1, 1990·Veterinary Immunology and Immunopathology·A H Saad, S el Deeb
Aug 1, 1987·American Journal of Reproductive Immunology and Microbiology : AJRIM·G Rai-el-BalhaaG Bodin

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