PMID: 9530930Apr 8, 1998Paper

Mitogenic signaling from P1 and P2 purinergic receptors to mitogen-activated protein kinase in human fetal astrocyte cultures

Neuroscience Letters
J T NearyS Zuniga

Abstract

To investigate potential trophic actions of extracellular ATP in human astrocytes, we have examined mitogenic signaling by purinergic receptors in cultures prepared from first trimester rostral central nervous system tissue. We found that ATP and ATPgammaS, a hydrolysis-resistant analog, stimulated DNA synthesis, thereby indicating that P2 purinergic receptors can stimulate mitogenic signaling in these cells. In addition, ATP activated a mitogen-activated protein kinase (MAPK) termed ERK (extracellular signal-regulated protein kinase), a key component of signal transduction pathways involved in cellular proliferation and differentiation. The activation of MAPK was mediated at least in part by P2 purinergic receptors, because a P2 purinoceptor antagonist, suramin, inhibited the ATP-evoked stimulation by 50%, whereas a P1 purinergic-receptor antagonist, 8-(para-sulfonphenyl)-theophylline, was without effect. In contrast to rat astrocytes, adenosine/P1 purinergic-receptor agonists, 2-chloroadenosine and 5'-N-ethylcarboxyamidoadenosine, stimulated MAPK activity and DNA synthesis in human astrocytes. A selective inhibitor of protein kinase C, Ro 31-8220, blocked the ability of ATP and adenosine analogs to stimulate MAPK, thereby ind...Continue Reading

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Citations

Sep 25, 2004·Journal of Cellular Physiology·R YaarKatya Ravid
Apr 28, 2006·Pflügers Archiv : European journal of physiology·Herbert Zimmermann
Apr 12, 2008·Purinergic Signalling·Stefania MerighiPier Andrea Borea
Nov 19, 2009·Purinergic Signalling·Elena Bulanova, Silvia Bulfone-Paus
May 1, 2012·Purinergic Signalling·Heike FrankePeter Illes
Jul 19, 2013·Journal of Molecular Neuroscience : MN·Maosheng Xia, Yue Zhu
Jun 28, 2000·Journal of the Autonomic Nervous System·J T Neary
Jul 2, 2003·Cellular Signalling·Gunnar Schulte, Bertil B Fredholm
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Feb 11, 2014·Neural Plasticity·Yann BernardinelliIrina Nikonenko
Jan 12, 2011·Cellular and Molecular Life Sciences : CMLS·Geoffrey Burnstock, Henning Ulrich
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