Mitogenomes from The 1000 Genome Project reveal new Near Eastern features in present-day Tuscans

PloS One
Alberto Gómez-CarballaAntonio Salas

Abstract

Genetic analyses have recently been carried out on present-day Tuscans (Central Italy) in order to investigate their presumable recent Near East ancestry in connection with the long-standing debate on the origins of the Etruscan civilization. We retrieved mitogenomes and genome-wide SNP data from 110 Tuscans analyzed within the context of The 1000 Genome Project. For phylogeographic and evolutionary analysis we made use of a large worldwide database of entire mitogenomes (>26,000) and partial control region sequences (>180,000). Different analyses reveal the presence of typical Near East haplotypes in Tuscans representing isolated members of various mtDNA phylogenetic branches. As a whole, the Near East component in Tuscan mitogenomes can be estimated at about 8%; a proportion that is comparable to previous estimates but significantly lower than admixture estimates obtained from autosomal SNP data (21%). Phylogeographic and evolutionary inter-population comparisons indicate that the main signal of Near Eastern Tuscan mitogenomes comes from Iran. Mitogenomes of recent Near East origin in present-day Tuscans do not show local or regional variation. This points to a demographic scenario that is compatible with a recent arrival of ...Continue Reading

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Citations

Jan 14, 2017·Forensic Science International. Genetics·Tanja HeinzAntonio Salas
Jul 16, 2016·Science·Farnaz BroushakiJoachim Burger
May 8, 2018·Genome Research·Alberto Gómez-CarballaAntonio Salas
Jun 7, 2020·International Journal of Legal Medicine·Slobodan DavidovicNatasa Kovacevic-Grujicic
Feb 21, 2018·PloS One·Piera Di LorenzoAlessandro Achilli

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Methods Mentioned

BETA
MDS

Software Mentioned

GATK
PhyloTree Build
samtools
Perl
R
Arlequin
Tuscan
samtools view
Haplogrep
house

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