PMID: 19920661Jun 1, 1995Paper

Mitomycin as adjunct chemotherapy with trabeculectomy in congenital and developmental glaucomas

Journal of Glaucoma
R SusannaM T Nicolela

Abstract

To report on sixty-eight patients (98 eyes) who were trabeculectomized with the use of mitomycin C as adjunctive therapy. Fifty-six patients (79 eyes) were followed for at least 6 months or had IOP of >21 mm HG or any complications that were considered end point for them. Forty-six were primary congenital glaucoma; one was Sturger Weber disease; five were Axenfeld-Rieger syndrome; two were Peters anomaly; one was congenital glaucoma associated with ectopia lentis and one aniridia. The mean age was 76.06 +/- 81.56 months (range, 1 month to 30 years). Fifty-three eyes (67.09%) were considered successful (IOP </= 21 mm Hg) with a mean follow-up of 17.30 +/- 7.98 months (range, 6-44 months). From these, 47 eyes (59.49%) had IOP </= 16 mm Hg. Twenty-three eyes had IOP of > 21 mm Hg (30.37%), one developed retinal detachment, (1.26%) two developed phthisis (2.53%), eight had flat anterior chamber (10.12%), two vitreous hemorrhage (2.53%), and four choroidal detachment (5.06%). Despite the number of complications, some of them very serious, the use of mitomycin seems to be a reasonable approach in these eyes with very poor surgical prognosis, otherwise candidates for setons.

Citations

Nov 20, 1998·American Journal of Ophthalmology·A D BeckR Noe
Nov 1, 1996·Australian and New Zealand Journal of Ophthalmology·Y KitazawaY Hagiwara
Jun 1, 1997·Ophthalmology·A K MandalA Jayagandan
Jun 1, 2014·Journal of Pediatric Ophthalmology and Strabismus·Sharaf KhanNeelakshi Bhagat
Jul 18, 2012·Journal of Pediatric Ophthalmology and Strabismus·Scott D Lawrence, Peter A Netland
Apr 26, 2003·Pediatric Clinics of North America·Michael A Kipp
Feb 5, 1999·American Journal of Ophthalmology·J A EnglertT A Cox
May 7, 2002·American Journal of Ophthalmology·Sharon F FreedmanLaura B Enyedi
Aug 21, 2013·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Nehal M S El Gendy, Jonathan C Song
Aug 17, 2001·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·D E Neely, D A Plager
Apr 30, 1999·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·S F FreedmanT A Cox
Jun 1, 1996·The British Journal of Ophthalmology·P T Khaw

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