PMID: 2501019Aug 15, 1989Paper

Mitomycin C adjuvant chemotherapy after Wertheim's hysterectomy for stage IB cervical cancer

Cancer
V Sivanesaratnam, P Jayalakshmi

Abstract

Patients undergoing radical surgical treatment for Stage IB and IIA cervical carcinoma are at high risk of developing local recurrence and/or distant metastases when one or more of the following factors are present: presence of metastatic pelvic lymph nodes, a large primary growth, full-thickness tumor invasion of the cervix, clinically undetected parametrial extension, and lymphatic/vascular channel permeation in the cervix by tumor cells. Carcinoma of the cervix appears to be behaving like a systemic disease. Therefore, systemic measures should be considered in its therapy. The authors report the initial experience with the use of mitomycin C as a single agent adjuvant in 16 patients with Stage IB carcinoma of the cervix who had undergone Wertheim radical hysterectomy and were thought to be in this high-risk group. Fourteen of the patients are alive and free of disease after durations of follow-up ranging from 16 to 38 months, the disease-free survival at a median follow-up of 29 months being 87.5%. One patient required discontinuation of adjuvant chemotherapy because of severe marrow toxicity; however, in view of the presence of a multiple risk factors, pelvic irradiation was given instead. She died 13 months later from diss...Continue Reading

References

Dec 1, 1976·American Journal of Obstetrics and Gynecology·G W Morley, J C Seski
Aug 1, 1987·The Australian & New Zealand Journal of Obstetrics & Gynaecology·V SivanesaratnamP Jayalakshmi
Nov 1, 1962·Cancer·G H FRIEDELL, L PARSONS

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Citations

Jan 1, 1995·La Revue de médecine interne·D Zylberait
Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·M. G. EtcheverryA. Nuñez De Pierro
Feb 1, 1991·The Australian & New Zealand Journal of Obstetrics & Gynaecology·P Jayalakshmi, V Sivanesarathnam
Feb 4, 2014·Expert Review of Anticancer Therapy·Roberto AngioliFrancesco Plotti
Jan 1, 1994·Clinical Oncology : a Journal of the Royal College of Radiologists·J P Logue, R D Hunter
Mar 10, 2001·Cancer Treatment Reviews·W T Bradner
Mar 22, 2002·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·T K ParkH J Mo
Dec 20, 2002·The Oncologist·Louis B HarrisonDaniel Shasha
Nov 23, 2016·The Cochrane Database of Systematic Reviews·Frederico S FalcettaDaniela D Rosa

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