PMID: 2505069Jul 1, 1989Paper

Mitomycin C-induced postmitotic fibroblasts retain the capacity to repair pyrimidine photodimers formed after UV-irradiation

Mutation Research
H J NiggliP I Francz

Abstract

The formation and excision of UV-C light-induced cyclobutane-type pyrimidine photodimers were determined in cultures of human skin fibroblasts at time zero and several weeks following treatment with mitomycin C (MMC). Characteristic morphological changes of the fibroblasts and specific shifts in the [35S]methionine polypeptide pattern of total cellular proteins support the notion that MMC accelerates the differentiation pathway from mitotic (MF) to post-mitotic fibroblasts (PMF). No discernible difference could be detected between the fluence-response curves of pyrimidine dimers for untreated and MMC-treated repair-deficient xeroderma pigmentosum cells of group A. Furthermore we investigated the removal of pyrimidine dimers in 3 normal human skin fibroblast strains frequently used in mutation, transformation and aging research. We were able to demonstrate that no significant difference exists in the rate and extent of the excision-repair response to thymine-containing pyrimidine dimers following UV-irradiation shortly after MMC treatment of fibroblasts and in the MMC-induced PMF stage of these cells.

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Citations

Oct 1, 1995·Mutation Research·V A Bohr, R M Anson
May 1, 1993·Journal of Photochemistry and Photobiology. B, Biology·H J Niggli
Nov 14, 2001·Journal of Photochemistry and Photobiology. B, Biology·H J NiggliL A Applegate
Jan 1, 1992·Archives of Gerontology and Geriatrics·K BayreutherH P Rodemann
May 25, 2005·Journal of Biomedical Optics·Hugo J NiggliFranco Musumeci
Mar 8, 1999·Molecular Cell Biology Research Communications : MCBRC·J B PetriU F Haustein

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