PMID: 2499780Jun 1, 1989Paper

Mitomycin-C-induced sister-chromatid exchanges and cell-cycle kinetics in lymphocytes from patients with Klinefelter syndrome

Mutation Research
Z YamagataM Higurashi

Abstract

The chromosomal sensitivity to mitomycin-C (MMC) and cell-cycle kinetics in cells from patients with Klinefelter syndrome, a sex chromosomal disorder giving a high risk of malignant tumor, were studied by techniques of sister-chromatid exchanges (SCEs). The frequencies of MMC-induced SCEs increased in proportion to the increase in MMC concentration in both patient and normal control cells. At low levels of MMC there were no significant differences in SCE frequencies between the patient and normal control cells, but at MMC concentrations of 3 X 10(-8) M (p less than 0.05) and 1 X 10(-7) M (p less than 0.01), significant increases in the frequency of MMC-induced SCEs were observed in cells from patients compared to cells from normal controls. Although the analysis of cell-cycle kinetics both after various culture times and after treatment with MMC revealed that there were no significant differences between the patient and normal control cells, patients with Klinefelter syndrome showed a tendency to cell-cycle delays after treatment with MMC in comparison with normal controls.

References

Mar 25, 1976·The New England Journal of Medicine·P S Gerald
Dec 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·S A Latt
Jan 23, 1965·British Medical Journal·A W JACKSONP J O'CONNOR

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Citations

Aug 28, 2001·Annales de génétique·A Bortolai, M I Melaragno

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