Mitomycin: clinical applications in ophthalmic practice

Drugs
Lekha M AbrahamIgal Leibovitch

Abstract

Mitomycin (mitomycin C; MMC) is an antibiotic isolated from Streptomyces caespitosus. The drug is a bioreductive alkylating agent that undergoes metabolic reductive activation, and has various oxygen tension-dependent cytotoxic effects on cells, including the cross-linking of DNA. It is widely used systemically for the treatment of malignancies, and has gained popularity as topical adjunctive therapy in ocular and adnexal surgery over the past 2 decades. In ophthalmic medicine, it is principally used to inhibit the wound healing response and reduce scarring of surgically fashioned ostia. Hence, it has been used as adjunctive therapy in various ocular surgeries, such as glaucoma filtering surgeries, dacryocystorhinostomy, corneal refractive surgery and surgeries for ocular cicatrisation. In addition, it has been used as an adjunct in the surgical management of pterygia, ocular surface squamous neoplasia, primary acquired melanosis with atypia and conjunctival melanoma. In many of these surgeries and ophthalmic pathologies, MMC showed a significant beneficial effect.

References

Aug 1, 1992·Ophthalmology·D S GartryJ Marshall
Jan 1, 1990·Journal of Ocular Pharmacology·C W ChenC C Lee
Jul 1, 1988·Survey of Ophthalmology·P A Jaros, V P DeLuise
Jun 1, 1988·Ophthalmology·G SinghC S Foster
Feb 1, 1987·The British Journal of Ophthalmology·R A Welham, A E Wulc
Nov 1, 1985·Ophthalmology·K R KenyonM E Hettinger
May 1, 1971·Archives of Ophthalmology·C E Iliff
Oct 1, 1971·American Journal of Ophthalmology·G Picó
Jun 1, 1984·Ophthalmology·R FolbergL E Zimmerman
Nov 1, 1982·Archives of Ophthalmology·J V LinbergR Barreras
Aug 1, 1980·Archives of Ophthalmology·F A JakobiecH R Shibata
Aug 1, 1995·American Journal of Ophthalmology·P P ChenP J McDonnell
Dec 1, 1994·The British Journal of Ophthalmology·M J Walland, G E Rose
Jan 1, 1995·Ophthalmology·K A Lamping, J K Belkin
Sep 15, 1994·American Journal of Ophthalmology·S SmithE B Dreyer
May 1, 1993·Archives of Ophthalmology·T C Spoor, J G McHenry
Oct 1, 1996·Archives of Ophthalmology·J Frucht-Pery, J Pe'er
Sep 1, 1996·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·J C NorregaardJ U Prause
Dec 24, 1997·Ophthalmology·D LeeS Y Reed
Mar 11, 1998·Survey of Ophthalmology·S Seregard
May 2, 1998·Archives of Ophthalmology·D S GreenfieldR Ritch
Jun 5, 1998·Ophthalmic Plastic and Reconstructive Surgery·J A ShieldsP De Potter
Jul 1, 1999·Current Opinion in Ophthalmology·P A Majmudar, R J Epstein
Sep 17, 1999·Ophthalmic Epidemiology·S M Saw, D Tan
Feb 24, 2000·The British Journal of Ophthalmology·C A McCartyH R Taylor
Jan 4, 2001·Clinical Eye and Vision Care·K T CorcoranD C Ward
Nov 16, 2001·Journal of Cataract and Refractive Surgery·R J Casson, J F Salmon
Jan 4, 2003·Ophthalmology·Abraham SolomonScheffer C G Tseng
Apr 11, 2003·Journal of Cataract and Refractive Surgery·Yuan-Chieh LeeI-Jong Wang
May 15, 2003·Survey of Ophthalmology·Paul J Lama, Robert D Fechtner
May 17, 2003·Ophthalmology·Eric D DonnenfeldSeth Biser
Jun 19, 2003·The British Journal of Ophthalmology·J LochheadJ F Salmon
Jan 27, 2004·Current Opinion in Ophthalmology·C Vass, R Menapace

❮ Previous
Next ❯

Citations

Aug 30, 2007·The Journal of Small Animal Practice·K KarasawaA Tanaka
Feb 12, 2011·Cutaneous and Ocular Toxicology·Tongabay CumurcuMufide Cavdar
Jun 11, 2015·The British Journal of Ophthalmology·Vinay KumarCharanya Ramachandran
Jul 1, 2015·American Journal of Rhinology & Allergy·Osama G Abdel-Naby Awad, Mostafa Sayed Hammad
Jan 1, 2013·American Journal of Rhinology & Allergy·Mirian Cabral Moreira de CastroOlindo Assis Martins-Filho
Jan 4, 2018·Taiwan Journal of Ophthalmology·Thiago Gonçalves Dos Santos MartinsDiogo Gonçalves Dos Santos Martins
Jan 23, 2020·American Journal of Clinical Dermatology·Joseph M GrimesBrian P Marr
Dec 14, 2011·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Vaidyanathan VenkatramanNirmal Shanmugasundaram
Mar 14, 2009·BJU International·Amit MevchaDavid A Gillatt
Mar 8, 2012·Nanomedicine·Steven J P McInnesNicolas H Voelcker
Jun 17, 2011·Journal of Neurophysiology·Daniel L AdamsJonathan C Horton
Oct 12, 2014·Journal of Glaucoma·Joanna Wasielica-PoslednikNorbert Pfeiffer
Sep 26, 2015·The British Journal of Ophthalmology·Leopoldo SpadeaPaolo Trabucco
Jul 1, 2013·Asia-Pacific Journal of Ophthalmology·Lindsay A McGrath, Graham A Lee
Mar 26, 2019·International Ophthalmology Clinics·Yongyun LiRenbing Jia
Nov 25, 2019·Ophthalmology and Therapy·Victoria M L Cohen, Roderick F O'Day
Dec 24, 2009·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Tingting ShaoJian Ge
Sep 8, 2011·International Ophthalmology Clinics·Sahar KohanimJames Chodosh
Jan 29, 2011·The Laryngoscope·Suppapong TirakunwichchaSiripong Sinprajakphon
Feb 8, 2007·Drugs·Lekha M AbrahamIgal Leibovitch
Nov 2, 2012·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Hatem M MareyAmin F Ellakwa
Jul 11, 2013·Ophthalmic Plastic and Reconstructive Surgery·Ayelet PrielDon O Kikkawa
Nov 14, 2012·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Manish Kumar SinhaMahesh Chandra
Jul 11, 2013·Ophthalmic Plastic and Reconstructive Surgery·Mohsen Bahmani KashkouliFarzad Pakdel
Jun 18, 2015·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Gemma JulioM Soledad Marqués-Calvo
Jan 13, 2015·Expert Review of Ophthalmology·James R WongCarol L Karp
Jan 5, 2008·Clinical & Experimental Ophthalmology·Jern Yee ChenRichard A Mills
Jan 11, 2007·Current Opinion in Otolaryngology & Head and Neck Surgery·Abtin TabaeeVijay K Anand
Sep 8, 2012·Ophthalmic Plastic and Reconstructive Surgery·Ayelet PrielDon O Kikkawa
Dec 24, 2011·Natural Product Reports·Qianjin KangLinquan Bai
Sep 21, 2011·Veterinary Ophthalmology·Rangan GuptaRajiv R Mohan
May 18, 2013·Current Opinion in Ophthalmology·Afshan A NanjiCarol L Karp
Dec 24, 2011·Journal of Strength and Conditioning Research·Andréia Silveira de SouzaLuiz Fernando Martins Kruel
Jul 16, 2019·Survey of Ophthalmology·Ritu NagpalNamrata Sharma
Feb 11, 2021·Eye·Roland HӧllhumerPamela Michelow

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.