PMID: 26331401Sep 4, 2015Paper

Mitomycin extravasation after postoperative instillation

Archivos españoles de urología
J Panach-NavarreteJ M Martínez-Jabaloyas

Abstract

To present the therapeutic management of severe complications related to postoperative mitomycin extravasation. Description of clinical cases, medical and surgical management and pathologic results of surgical specimens. We report two cases of patients with extravesical mitomycin leakage after postoperative instillation. No bladder perforation was evident during tumor surgery. In both cases radical cystectomy was required. Postoperative mitomycin instillation may have undesirable consequences. The possible problems derived from its administration must be known, and each case must be individualized before administering this chemotherapy.

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