MitoNEET in Perivascular Adipose Tissue Prevents Arterial Stiffness in Aging Mice

Cardiovascular Drugs and Therapy
Lin ChangY Eugene Chen

Abstract

Arterial stiffness is an inevitable consequence of the aging process and is considered an early stage in the development of cardiovascular diseases. The perivascular adipose tissue (PVAT) is a distinct functional integral layer of the vasculature actively involved in blood pressure regulation and atherosclerosis development via PVAT-derived paracrine/autocrine factors. However, there is little knowledge regarding the relationship between PVAT and arterial stiffness. Using unique mice lacking PVAT, high-fat diet-induced obesity, and in mice overexpressing brown adipocyte selective mitoNEET, we investigated the relationship between PVAT and arterial stiffness in mice. We found that lack of PVAT enhanced arterial stiffness in aging mice. High-fat diet feeding of aging C57BL/6J wild-type mice significantly induced hypertrophic PVAT and enhanced arterial stiffness. Furthermore, the expression of mitoNEET, a mitochondrial membrane protein related to energy expenditure, was significantly increased by pioglitazone treatment, while reduced in the hypertrophic PVAT induced by high-fat diet. Overexpression of mitoNEET in PVAT reduced the expression of inflammatory genes and was associated with lower pulse wave velocity in aging mice. Thes...Continue Reading

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Citations

Oct 12, 2018·Cardiovascular Drugs and Therapy·Y Eugene Chen
Sep 26, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Jifeng ZhangY Eugene Chen
Mar 20, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Lin ChangY Eugene Chen
Feb 6, 2020·Scientific Reports·Stephanie W WattsSara Roccabianca
Sep 13, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Ha Won KimNeal L Weintraub
Aug 31, 2021·Frontiers in Endocrinology·Yaozhi ChenYunxia Liu

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