Mitophagy, Mitochondrial Homeostasis, and Cell Fate

Frontiers in Cell and Developmental Biology
Kaili MaQuan Chen

Abstract

Mitochondria are highly plastic and dynamic organelles that have graded responses to the changing cellular, environmental, and developmental cues. Mitochondria undergo constant mitochondrial fission and fusion, mitochondrial biogenesis, and mitophagy, which coordinately control mitochondrial morphology, quantity, quality, turnover, and inheritance. Mitophagy is a cellular process that selectively removes the aged and damaged mitochondria via the specific sequestration and engulfment of mitochondria for subsequent lysosomal degradation. It plays a pivotal role in reinstating cellular homeostasis in normal physiology and conditions of stress. Damaged mitochondria may either instigate innate immunity through the overproduction of ROS or the release of mtDNA, or trigger cell death through the release of cytochrome c and other apoptogenic factors when mitochondria damage is beyond repair. Distinct molecular machineries and signaling pathways are found to regulate these mitochondrial dynamics and behaviors. It is less clear how mitochondrial behaviors are coordinated at molecular levels. BCL2 family proteins interact within family members to regulate mitochondrial outer membrane permeabilization and apoptosis. They were also describe...Continue Reading

References

Jul 1, 1979·Archives of Biochemistry and Biophysics·D R Hunter, R A Haworth
Dec 10, 1999·Nature·P SutovskyG Schatten
Dec 25, 2002·The Journal of Cell Biology·Mariusz KarbowskiRichard J Youle
Feb 18, 2003·Human Molecular Genetics·Frédéric DariosAlexis Brice
Apr 17, 2004·Science·Enza Maria ValenteNicholas W Wood
Sep 24, 2005·Cell·Sophie PattingreBeth Levine
Mar 18, 2006·Molecular Cell·Petrina DelivaniSeamus J Martin
Oct 4, 2006·Molecular and Cellular Biology·Philippe A ParoneJean-Claude Martinou
Oct 13, 2006·Nature·Mariusz KarbowskiRichard J Youle
Nov 23, 2006·The Journal of Biological Chemistry·Kyle A Rasbach, Rick G Schnellmann
Dec 13, 2006·The Journal of Experimental Medicine·Xinqi LiuPhilippa Marrack
Feb 16, 2007·The Journal of Biological Chemistry·Naoko TaguchiKatsuyoshi Mihara
Mar 23, 2007·Autophagy·Ingrid KissováNadine Camougrand
Jun 8, 2007·The Journal of Biological Chemistry·Chuang-Rung Chang, Craig Blackstone
Jul 4, 2007·The Journal of Cell Biology·Mariusz KarbowskiRichard J Youle
Aug 22, 2007·The Journal of Cell Biology·Lorena GriparicAlexander M van der Bliek
Feb 6, 2008·Proceedings of the National Academy of Sciences of the United States of America·Hongmei LiElizabeth A Jonas
Jun 24, 2008·Molecular Cell·Yongjie WeiBeth Levine
Aug 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·Clement A GautierJie Shen
Aug 30, 2008·Molecular Cell·Clare SheridanSeamus J Martin
Dec 10, 2008·The Journal of Clinical Investigation·Abhinav DiwanGerald W Dorn
Mar 4, 2009·The Journal of Cell Biology·Sarah B BermanJ Marie Hardwick
Jun 12, 2009·Current Opinion in Cell Biology·Jean-Claude FarréMichael Thumm
Jul 22, 2009·Developmental Cell·Tomotake KankiDaniel J Klionsky
Nov 18, 2009·Molecular Cell·Arnaud Autret, Seamus J Martin
Dec 17, 2009·EMBO Reports·Ivana NovakIvan Dikic
Dec 30, 2009·The Journal of Cell Biology·Brian HeadAlexander M van der Bliek
Feb 18, 2010·Molecular Cell·Jerry E ChipukDouglas R Green

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Citations

Sep 24, 2020·International Journal of Molecular Sciences·Alex E RyckmanJagdeep S Walia
Oct 8, 2020·Nutritional Neuroscience·Francesco VisioliEmma Burgos-Ramos
Jan 14, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Myung Hee KimDae Yu Kim
Dec 29, 2020·Frontiers in Cellular and Infection Microbiology·Shirley Luckhart, Michael A Riehle
Dec 18, 2020·Frontiers in Cell and Developmental Biology·Miaolin ZengHaitong Wan
Dec 29, 2020·Frontiers in Oncology·Alessandra FerraresiCiro Isidoro
Feb 10, 2021·Infection and Immunity·Kristin L Patrick, Robert O Watson
Apr 4, 2021·Antioxidants·Lucie Valek, Irmgard Tegeder
Apr 4, 2021·International Journal of Molecular Sciences·Hansruedi Büeler
Apr 20, 2021·DNA and Cell Biology·Pankaj Prasun
May 8, 2021·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Zeynep Banu DoğanlarEsra Turgut
Jun 1, 2021·Frontiers in Cell and Developmental Biology·Ziye RongYanan Yang
Jun 3, 2021·Pharmaceuticals·Barbara MiziakStanisław J Czuczwar
Jun 3, 2021·Cells·Lorenzo ModestiPaolo Pinton
Jun 5, 2021·Advanced Drug Delivery Reviews·Yiyuan KangLongquan Shao
Jun 3, 2021·Biomedicines·Ana P MarquesCláudia F Pereira
Jun 8, 2021·BioMed Research International·Sung Il ChoHansoo Song
Jul 3, 2021·Biology·Carine JoffreVéronique Mansat-De Mas
Jun 25, 2021·Frontiers in Cell and Developmental Biology·Cheng-Long ZhuXiao-Ming Deng
Aug 20, 2021·Antioxidants & Redox Signaling·Luciane C Alberici, Helena C F Oliveira
Sep 7, 2021·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Tongyu C WikramanayakeRalf Paus
Sep 18, 2021·Journal of Cellular and Molecular Medicine·Ling LiJingping Liu

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Methods Mentioned

BETA
ubiquitination
GTPase
environmental stress

Related Concepts

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis