Abstract
Parkinson's disease (PD) is characterized by the degeneration of dopaminergic neurons in the substantia nigra compacta (SNc). Although mitochondrial dysfunction is the critical factor in the pathogenesis of PD, the underlying molecular mechanisms are not well understood, and as a result, effective medical interventions are lacking. Mitochondrial fission and fusion play important roles in the maintenance of mitochondrial function and cell viability. Here, we investigated the effects of MitoQ, a mitochondria-targeted antioxidant, in 6-hydroxydopamine (6-OHDA)-induced in vitro and in vivo PD models. We observed that 6-OHDA enhanced mitochondrial fission by decreasing the expression of Mfn1, Mfn2 and OPA1 as well as by increasing the expression of Drp1 in the dopaminergic (DA) cell line SN4741. Notably, MitoQ treatment particularly upregulated the Mfn2 protein and mRNA levels and promoted mitochondrial fusion in the presence of 6-OHDA in a Mfn2-dependent manner. In addition, MitoQ also stabilized mitochondrial morphology and function in the presence of 6-OHDA, which further suppressed the formation of reactive oxygen species (ROS), as well as ameliorated mitochondrial fragmentation and cellular apoptosis. Moreover, the activation o...Continue Reading
Citations
May 20, 2019·Journal of Cellular and Molecular Medicine·Long XuYideng Jiang
Feb 6, 2020·Cell Proliferation·Liang KangXiaozhi Liu
Jan 11, 2020·Cell Proliferation·Xun WuYan Qu
May 22, 2020·Neuroscience Bulletin·Xun WuYan Qu
Feb 20, 2019·Frontiers in Neuroscience·Xiu-Yun ZhaoQuan-Hong Ma
Aug 15, 2019·Neurochemical Research·Qi ZhangHao Meng
Aug 10, 2019·Molecular Pain·Wei MengMin Xie
May 8, 2020·Oxidative Medicine and Cellular Longevity·Monika PichlaIzabela Sadowska-Bartosz
May 30, 2020·International Journal of Molecular Sciences·Serena StangaAlessandro Vercelli
Jul 3, 2019·International Journal of Molecular Sciences·Jessica H HartmanJoel N Meyer
May 30, 2020·Cellular and Molecular Neurobiology·Mohd SalmanSuhel Parvez
Sep 11, 2020·Neural Plasticity·Baoyi FengHao Wu
Oct 28, 2019·Phytotherapy Research : PTR·Ehraz AnisM Mobarak Hossain
Aug 21, 2020·Critical Reviews in Food Science and Nutrition·Jing YangJiajia Song
Oct 18, 2019·Frontiers in Neuroscience·Dario ValdinocciDean L Pountney
Jan 7, 2020·Translational Stroke Research·Xun WuYan Qu
Jul 14, 2020·Frontiers in Cellular Neuroscience·Xu YanXinwen Zhang
Feb 1, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Seulhee KimLufang Zhou
Oct 20, 2020·Journal of Parkinson's Disease·Max BorscheAnne Grünewald
Nov 6, 2020·Critical Reviews in Biochemistry and Molecular Biology·Martin D Brand
Dec 1, 2020·Acta Biochimica Et Biophysica Sinica·Min XieHaili Zhu
Aug 3, 2019·European Journal of Medicinal Chemistry·Lucia BiasuttoMario Zoratti
Jan 16, 2021·European Journal of Pharmacology·Bhupesh VaidyaShyam Sunder Sharma
Jan 28, 2021·Antioxidants·Kristell Le GalMartin O Bergo
Feb 13, 2021·Cells·Laura J McMeekinRita M Cowell
Oct 29, 2020·Neuroscience Bulletin·Jianing LuoYan Qu
Jun 11, 2021·Neurochemistry International·Tanuja AmbekarDharmendra Kumar Khatri
Jun 21, 2021·Redox Biology·Cláudia M DeusPaulo J Oliveira
Aug 3, 2021·Oxidative Medicine and Cellular Longevity·Yi LuanYang Yang
Jun 14, 2019·Experimental Cell Research·Xiaoling ZhangXiaoqun Ge
Jul 27, 2021·ASN Neuro·Bipul RayMeena Kishore Sakharkar
Aug 25, 2021·Oxidative Medicine and Cellular Longevity·Zijing ZhuGuohua Ding
Nov 3, 2021·Molecular Neurobiology·Rishika DhapolaDibbanti HariKrishna Reddy